Description

2-O,3-O:5-O,6-o-Bis(Ethylboranediyl)-D-Gulonic Acid 1,4-Lactone is a specialized organoboron derivative of D-gulonic acid, serving as a key chiral intermediate and protecting group reagent in advanced organic synthesis. Its value lies in enabling precise stereochemical control and facilitating complex multi-step reactions, particularly in the synthesis of biologically active molecules. This compound is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries who require high-purity, reliable building blocks for drug discovery and development.

Application

• Pharmaceutical Intermediate: A critical chiral building block for the synthesis of complex drug candidates, particularly those containing sugar or polyol motifs.
• Asymmetric Synthesis: Used as a boron-based protecting group or directing agent to control stereoselectivity in catalytic and stoichiometric reactions.
• Agrochemical Research: Serves as a precursor in the development of novel herbicides, fungicides, or plant growth regulators with specific chiral configurations.
• Fine Chemical Manufacturing: Employed in the production of high-value specialty chemicals, flavors, and fragrances requiring precise stereochemistry.
• Academic & R&D Laboratories: A valuable reagent for methodological development in organic chemistry, exploring new boron-mediated transformations.
• Glycochemistry & Carbohydrate Chemistry: Used in the synthesis and modification of complex carbohydrates, glycoconjugates, and glycomimetics.

Basic Information

Product Name	2-O,3-O:5-O,6-o-Bis(Ethylboranediyl)-D-Gulonic Acid 1,4-Lactone
CAS No.	74128-60-2
Molecular Formula	C10H16B2O8
Molecular Weight	277.85 g/mol
Synonyms	D-Gulonic Acid, 1,4-Lactone, 2,3:5,6-Bis-O-[(ethylboro)diyl]-; 2,3:5,6-Bis-O-(ethylboranediyl)-D-gulono-1,4-lactone; Ethylboronate Protected D-Gulonolactone; D-Gulono-1,4-lactone cyclic ethylboronate; Bis(ethylboronate) Derivative of D-Gulonolactone; (3aR,5S,6R,6aR)-5-[(Ethoxyboranyl)oxy]-2,2-dimethyl-6-[(ethoxyboranyl)oxy]tetrahydrofuro[2,3-d][1,3,2]dioxaborole-4(4aH)-one (alternative representation)
EINECS	Contact for details

Quality Control

Our production of 2-O,3-O:5-O,6-o-Bis(Ethylboranediyl)-D-Gulonic Acid 1,4-Lactone adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. The material is characterized and released according to comprehensive in-house specifications, which typically include identity confirmation by spectroscopic methods (NMR, IR), purity assessment by HPLC, and control of residual solvents. A Certificate of Analysis (COA) detailing all relevant parameters is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation due to moisture absorption. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.