Description

(-)-(18-Crown-6)-2,3,11,12-Tetracarboxylic Acid is a highly functionalized, chiral derivative of the classic 18-crown-6 ether, distinguished by the introduction of four carboxylic acid groups at specific positions on the macrocyclic ring. This compound matters as a sophisticated supramolecular building block and chiral selector, offering enhanced metal ion binding affinity and selectivity due to its pre-organized cavity and multiple coordination sites. It is primarily needed by researchers and manufacturers in asymmetric synthesis, chiral separation science, and the development of advanced sensor materials and catalysts.

Application

• Chiral Resolution Agent: As a chiral shift reagent or selector in NMR spectroscopy and chiral chromatography (HPLC, CE) for the separation and analysis of enantiomers.
• Asymmetric Catalyst Ligand: A precursor for creating chiral ligands used in transition metal-catalyzed asymmetric reactions, such as hydrogenations and oxidations.
• Ion-Selective Materials: A key component in the synthesis of ionophores for ion-selective electrodes and sensors, particularly for alkali and alkaline earth metal ions.
• Supramolecular Assembly: A versatile building block for constructing complex molecular machines, frameworks, and host-guest systems due to its multiple binding sites and chiral center.
• Polymer Modification: Used to impart chirality and ion-binding properties to polymers for specialized membrane and separation technologies.
• Academic & Pharmaceutical Research: A valuable tool in fundamental studies of molecular recognition and in the development of novel pharmaceutical intermediates.

Basic Information

Product Name	(-)-(18-Crown-6)-2,3,11,12-Tetracarboxylic Acid
CAS No.	73891-15-3
Molecular Formula	C18H24O14
Molecular Weight	464.38 g/mol
Synonyms	(−)-2,3,11,12-Tetracarboxy-18-crown-6; (18-Crown-6)-2,3,11,12-tetracarboxylic acid, (-)-; (-)-18-Crown-6-tetracarboxylic acid; (S,S)-18-Crown-6-2,3,11,12-tetracarboxylic acid; Chiral 18-crown-6 tetracarboxylate; TC18C6; Tetracarboxy crown ether
EINECS	Contact for details

Quality Control

Our (-)-(18-Crown-6)-2,3,11,12-Tetracarboxylic Acid is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing to ensure high chemical purity and chiral integrity. A comprehensive Certificate of Analysis (COA) is provided, detailing key parameters such as assay, enantiomeric excess, and impurity profiles. We support research and development with consistent quality and full traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Enantiomeric Excess (ee)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.