Description

Kryptofix(R) 221 is a high-purity, non-ionic phase-transfer catalyst and complexing agent, specifically a diaza-crown ether derivative. Its primary value lies in its exceptional ability to solubilize inorganic salts in organic solvents, facilitating critical reactions in synthetic chemistry. This product is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors, particularly for nucleophilic fluorination reactions using alkali metal fluorides. CAS No. 31364-42-8.

Application

• Nucleophilic Fluorination Reactions: Crucial catalyst for the preparation of fluorinated pharmaceuticals and PET (Positron Emission Tomography) radiotracers, enabling reactions with potassium fluoride (KF) or cesium fluoride (CsF).
• Phase-Transfer Catalysis (PTC): Widely used to accelerate reactions between reagents in immiscible phases, improving yields and selectivity in alkylation, esterification, and etherification processes.
• Complexation Agent: Forms stable complexes with alkali and alkaline earth metal cations, used in ion-selective electrodes, sensors, and separation technologies.
• Polymerization Aid: Serves as an activator or catalyst component in the synthesis of specialized polymers and resins.
• Organic Synthesis: Facilitates various substitution, condensation, and cyclization reactions that require the activation of anionic nucleophiles in non-polar media.
• Agrochemical Synthesis: Employed in the production of advanced, high-performance herbicides, fungicides, and insecticides requiring fluorinated intermediates.

Basic Information

Product Name	Kryptofix(R) 221
CAS No.	31364-42-8
Molecular Formula	C14H32N2O4
Molecular Weight	292.42 g/mol
Synonyms	4,7,13,16,21,24-Hexaoxa-1,10-diazabicyclo[8.8.8]hexacosane; Kryptofix 221; K-221; K222; 1,10-Diaza-4,7,13,16,21,24-hexaoxabicyclo[8.8.8]hexacosane; Diaza-18-crown-6 derivative; Kryptofix(R) 2.2.1; 4,7,13,16,21,24-Hexaoxa-1,10-diazabicyclo[8.8.8]hexacos-5-ene (common misnomer)
EINECS	250-578-5

Quality Control

Our Kryptofix(R) 221 is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for sensitive applications like radiopharmaceutical synthesis. Each lot undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation and maintain efficacy.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.