Description

α-(Fluoromethyl)Tryptophan is a fluorinated derivative of the essential amino acid tryptophan, characterized by the introduction of a fluoromethyl group at the alpha position. This structural modification is of significant interest in medicinal chemistry and pharmaceutical research, as it can dramatically alter the metabolic stability, bioavailability, and binding affinity of peptide-based compounds. This high-purity building block is primarily utilized by research institutions and pharmaceutical developers engaged in the synthesis of novel therapeutic agents, diagnostic probes, and biochemical tools.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of fluorinated peptides and peptidomimetics with enhanced metabolic stability.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to investigate the role of fluorine in drug-receptor interactions.
• Proteomics & Biochemistry: Serves as a precursor for labeling agents or affinity probes to study enzyme mechanisms and protein function.
• Positron Emission Tomography (PET) Tracer Development: Potential precursor for fluorine-18 (18F) labeled compounds used in medical imaging.
• Agrochemical Research: Exploration of novel fluorinated amino acid analogs for the development of new pesticides or plant growth regulators.

Basic Information

Product Name	α-(Fluoromethyl)Tryptophan
CAS No.	73804-81-6
Molecular Formula	C13H15FN2O2
Molecular Weight	250.27 g/mol
Synonyms	2-Amino-3-(1H-indol-3-yl)-4-fluorobutanoic acid; (2S)-2-Amino-3-(1H-indol-3-yl)-4-fluorobutanoic acid; α-Fluoromethyltryptophan; (α-Fluoromethyl)-DL-tryptophan; DL-α-(Fluoromethyl)tryptophan; Tryptophan, α-(fluoromethyl)-; Fluoromethyltryptophan
EINECS	Contact for details

Quality Control

Our α-(Fluoromethyl)Tryptophan is manufactured under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identity confirmation via spectroscopic methods (NMR, IR, MS). We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research or development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity	Contact for details
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.