Description

Epi-Triptolide is a diterpenoid epoxide compound of significant interest in pharmaceutical research and development. This specific isomer is valued for its potent biological activity and serves as a crucial reference standard and synthetic intermediate. It is primarily utilized by research institutions and pharmaceutical companies engaged in the discovery of novel therapeutic agents. The compound is supplied to meet the stringent purity requirements of modern analytical and synthetic chemistry.

Application

• Pharmaceutical Reference Standard: Used for the qualitative and quantitative analysis of triptolide-related compounds in drug development and quality control laboratories.
• Biochemical Research: Employed in in vitro and in vivo studies to investigate mechanisms of action, pharmacokinetics, and structure-activity relationships (SAR).
• Active Pharmaceutical Ingredient (API) Intermediate: Serves as a key building block in the multi-step synthesis of potential drug candidates targeting inflammatory and autoimmune pathways.
• Analytical Method Development: Critical for calibrating equipment and validating HPLC, LC-MS, and other chromatographic methods for purity and potency assays.
• Academic Research: Used in university and institutional labs for fundamental studies in medicinal chemistry and natural product pharmacology.

Basic Information

Product Name	Epi-Triptolide
CAS No.	73543-06-3
Molecular Formula	C20H24O6
Molecular Weight	360.40 g/mol
Synonyms	(5R,5aR,6aS,7R,8S,8aR,9R,10aR)-5,8-Epoxy-5,6,6a,7,8,8a,9,10-Octahydro-9-hydroxy-7-methyl-11,13-bis(methylene)-6H-5,9-Epoxybenzo[3,4]cycloocta[1,2-f][2]benzofuran-1(12H)-one; Epitriptolide; (5R,5aR,6aS,7R,8S,8aR,9R,10aR)-5,8-Epoxy-9-hydroxy-7-methyl-11,13-bis(methylene)-6H-5,9-epoxybenzo[3,4]cycloocta[1,2-f][2]benzofuran-1(12H)-one; Triptolide, epi-
EINECS	Contact for details

Quality Control

Our Epi-Triptolide is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity determination and spectroscopic methods (NMR, MS) for structural confirmation, to ensure it meets the high standards required for research and development. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting the specific results for key parameters such as assay, related substances, and residual solvents.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing at 2-8°C. The compound is light-sensitive; prolonged exposure to light should be avoided to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Unknown Impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.