Description

4'-tert-Butyl-2,2,2-Trifluoroacetophenone is a high-purity fluorinated aromatic ketone building block, essential for advanced organic synthesis. Its unique trifluoroacetyl group adjacent to a tert-butyl-substituted aromatic ring makes it a valuable intermediate for creating compounds with enhanced metabolic stability and lipophilicity. This product is primarily utilized by research and development chemists and process engineers in the pharmaceutical and agrochemical industries for the synthesis of active ingredients and novel chemical entities.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in the synthesis of molecules containing trifluoromethyl ketone pharmacophores.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides where the trifluoromethyl group improves biological activity and environmental stability.
• Ligand and Catalyst Precursor: Serves as a starting material for the synthesis of specialized ligands in asymmetric catalysis and organometallic chemistry.
• Material Science Research: Employed in the development of novel fluorinated polymers and advanced organic materials with specific optical or electronic properties.
• Chemical Reference Standard: Used as an analytical standard in quality control laboratories for method development and validation.

Basic Information

Product Name	4'-tert-Butyl-2,2,2-Trifluoroacetophenone
CAS No.	73471-97-3
Molecular Formula	C₁₂H₁₃F₃O
Molecular Weight	230.23 g/mol
Synonyms	1-[4-(1,1-Dimethylethyl)phenyl]-2,2,2-trifluoroethanone; 2,2,2-Trifluoro-1-[4-(tert-butyl)phenyl]ethanone; 4-(tert-Butyl)phenyl trifluoromethyl ketone; p-tert-Butyl-α,α,α-trifluoroacetophenone; 4'-tert-Butyl-α,α,α-trifluoroacetophenone; 4-(1,1-Dimethylethyl)-α,α,α-trifluoroacetophenone; Trifluoro-4-tert-butylacetophenone
EINECS	Contact for details

Quality Control

Our 4'-tert-Butyl-2,2,2-Trifluoroacetophenone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing including HPLC, GC, NMR, and IR spectroscopy to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our quality commitment aligns with cGMP principles where applicable, ensuring reliability for your most demanding synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed to prevent moisture absorption and potential contamination.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.