Description

(4R,4As)-1-Acetyl-4,4A,5,6-Tetrahydro-4,7-Dimethylnaphthalen-2(3H)-One is a high-purity, specialized organic compound with a defined stereochemistry, serving as a critical chiral intermediate in advanced chemical synthesis. Its precise molecular architecture makes it valuable for constructing complex molecules where stereochemical control is paramount. This compound is essential for research and development in the pharmaceutical and fine chemical industries, particularly for the synthesis of novel active pharmaceutical ingredients (APIs) and other high-value specialty chemicals.

Application

• Pharmaceutical Intermediate: A key chiral building block in the synthesis of novel drug candidates and active pharmaceutical ingredients (APIs), especially in therapeutic areas requiring stereospecificity.
• Fine Chemical Synthesis: Used in the research and production of complex, high-value specialty chemicals, including flavors, fragrances, and advanced materials.
• Asymmetric Catalysis Research: Serves as a substrate or ligand precursor in the development and study of new asymmetric catalytic processes.
• Academic & Industrial R&D: A valuable reagent for chemical research in academic institutions and corporate R&D laboratories focused on organic and medicinal chemistry.
• Process Chemistry Development: Employed in scaling up synthetic routes from laboratory to pilot plant and commercial production scales.

Basic Information

Product Name	(4R,4As)-1-Acetyl-4,4A,5,6-Tetrahydro-4,7-Dimethylnaphthalen-2(3H)-One
CAS No.	72943-97-6
Molecular Formula	C₁₄H₂₀O₂
Molecular Weight	220.31 g/mol
Synonyms	1-Acetyl-4,4a,5,6-tetrahydro-4,7-dimethyl-2(3H)-naphthalenone (4R,4aR)-isomer; (4R,4aR)-1-Acetyl-4,4a,5,6-tetrahydro-4,7-dimethylnaphthalen-2(3H)-one; (4R,4aR)-4,4a,5,6-Tetrahydro-4,7-dimethyl-1-acetyl-2(3H)-naphthalenone; 72943-97-6; Chiral tetralone derivative; Acetyl dimethyl tetralone
EINECS	Contact for details

Quality Control

Our (4R,4As)-1-Acetyl-4,4A,5,6-Tetrahydro-4,7-Dimethylnaphthalen-2(3H)-One is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including chiral purity analysis by HPLC, to ensure it meets the high standards required for advanced synthetic applications. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming identity, purity, and other critical specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. For long-term storage under inert atmosphere, please contact us for specific recommendations.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.