Description

4,4,5,5-Tetramethyl-2-(Prop-1-Enyl)-1,3,2-Dioxaborolane is a high-purity, versatile organoboron reagent, specifically a vinylboronic ester, widely used in advanced organic synthesis. Its primary value lies in enabling efficient and selective carbon-carbon bond formation, particularly in Suzuki-Miyaura cross-coupling reactions, which are fundamental to modern pharmaceutical and materials science research. This compound is essential for R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries who require reliable building blocks for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate Synthesis: A key coupling partner for constructing biaryl and styrenyl motifs in active pharmaceutical ingredients (APIs) and drug candidates.
• Agrochemical Development: Used in the synthesis of novel herbicides, fungicides, and insecticides that require specific aromatic or olefinic structures.
• Material Science & OLED Research: Serves as a precursor for creating conjugated polymers and organic light-emitting diode (OLED) materials through palladium-catalyzed cross-coupling.
• Ligand & Catalyst Design: Employed in the preparation of novel bidentate or monodentate ligands for transition metal catalysis.
• Chemical Biology & Probe Development: Utilized for the site-specific incorporation of vinyl groups into biomolecules or for creating molecular imaging probes.
• Academic & Industrial R&D: A staple reagent in laboratory-scale research for method development and exploring new synthetic pathways.

Basic Information

Product Name	4,4,5,5-Tetramethyl-2-(Prop-1-Enyl)-1,3,2-Dioxaborolane
CAS No.	72824-05-6
Molecular Formula	C9H17BO2
Molecular Weight	168.04 g/mol
Synonyms	1-Propenylboronic acid pinacol ester; 2-(1-Propenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; (1-Propenyl)boronic acid pinacol ester; 1-PropenylBpin; Vinylboronic ester pinacol; 1-Propenyl pinacol boronate; Allylboronic acid pinacol ester (related); trans-1-Propenylboronic acid pinacol ester (isomer specific)
EINECS	Contact for details

Quality Control

Our 4,4,5,5-Tetramethyl-2-(Prop-1-Enyl)-1,3,2-Dioxaborolane is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for demanding synthetic applications. Each lot undergoes rigorous analytical testing, including NMR (¹H, ¹³C, ¹¹B), GC/HPLC for purity, and color/clarity assessment. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We adhere to relevant industry standards and can support development under cGMP guidelines for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (argon or nitrogen) for prolonged use or when dispensing from the original container to prevent hydrolysis and maintain reactivity.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (NMR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.