Description

1H-Benzotriazole-1-Carboxaldehyde is a versatile and high-value heterocyclic building block, essential for advanced organic synthesis. Its core value lies in its bifunctional reactivity, serving as a key precursor for constructing complex molecules in pharmaceutical and agrochemical research. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for applications in medicinal chemistry and material science.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in the development of protease inhibitors and other therapeutic agents.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides, herbicides, and fungicides, leveraging its heterocyclic structure.
• Peptidomimetics & PROTACs: Serves as a key component in the design of peptidomimetic compounds and Proteolysis Targeting Chimeras (PROTACs) for targeted protein degradation.
• Corrosion Inhibitor Precursor: Acts as a starting material for synthesizing specialized benzotriazole derivatives used in metal surface treatment and corrosion inhibition formulations.
• Polymer Chemistry: Employed in the synthesis of functional polymers and dyes, where its aldehyde group enables further chemical modifications.
• Cross-Coupling Reactions: Utilized in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira) to introduce the benzotriazole moiety into complex molecular architectures.

Basic Information

Product Name	1H-Benzotriazole-1-Carboxaldehyde
CAS No.	72773-04-7
Molecular Formula	C7H5N3O
Molecular Weight	147.14 g/mol
Synonyms	1H-Benzotriazole-1-carboxaldehyde; 1H-Benzotriazol-1-yl-methanal; 1-Formylbenzotriazole; 1-Carboxyaldehydebenzotriazole; Benzotriazole-1-carbaldehyde; N-Formylbenzotriazole; 1-(Formyl)benzotriazole; Bt-CHO
EINECS	Contact for details

Quality Control

Our 1H-Benzotriazole-1-Carboxaldehyde is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and IR spectroscopy, to ensure high purity and consistency. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Due to its sensitivity, the product should be stored under an inert atmosphere to prevent oxidation and kept away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	118 - 122 °C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.