Description

4-(Bromomethyl)-2,2-Difluoro-1,3-Benzodioxole is a versatile and highly functionalized benzodioxole derivative, serving as a critical building block in advanced organic synthesis. Its value lies in the strategic combination of a reactive bromomethyl group and a stable, electron-withdrawing difluorobenzodioxole moiety, enabling precise molecular construction. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, where it is used to develop novel active ingredients and complex intermediates.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in the synthesis of fluorinated drug candidates targeting CNS disorders, oncology, and metabolic diseases.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the difluorobenzodioxole structure can enhance biological activity and environmental stability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands and organocatalysts used in asymmetric synthesis and cross-coupling reactions.
• Material Science Research: Employed in the synthesis of novel fluorinated polymers, liquid crystals, and electronic materials that require specific dielectric and stability properties.
• Chemical Biology Probes: Useful for synthesizing tagged molecules and probes for studying biological pathways and protein interactions due to its reactive handle.

Basic Information

Product Name	4-(Bromomethyl)-2,2-Difluoro-1,3-Benzodioxole
CAS No.	72769-05-2
Molecular Formula	C8H5BrF2O2
Molecular Weight	251.03 g/mol
Synonyms	2,2-Difluoro-4-(bromomethyl)-1,3-benzodioxole; 4-Bromomethyl-2,2-difluoro-1,3-benzodioxole; 1,3-Benzodioxole, 4-(bromomethyl)-2,2-difluoro-; 2,2-Difluoro-4-(bromomethyl)benzo[d][1,3]dioxole; Benzo[1,3]dioxole, 4-(bromomethyl)-2,2-difluoro-; 72769-05-2
EINECS	Contact for details

Quality Control

Our 4-(Bromomethyl)-2,2-Difluoro-1,3-Benzodioxole is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and elemental analysis, to ensure high purity and batch-to-batch consistency suitable for research and scale-up. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be opaque or stored in darkness.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.