Description

4-Thiazolidinecarboxylicacid,5-Methyl-,(4R-Trans)-(9Ci) CAS NO 72274-40-9 is a high-purity, stereochemically defined thiazolidine derivative. This compound serves as a critical chiral building block and intermediate in advanced organic synthesis, particularly for pharmaceuticals and bioactive molecules. It is essential for research and development chemists in the pharmaceutical, agrochemical, and fine chemical industries who require precise stereochemistry and high-quality intermediates for complex synthesis.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the development of novel active pharmaceutical ingredients (APIs), especially in therapeutic areas targeting metabolic and neurological disorders.
• Peptidomimetics Research: Used in the design and synthesis of peptidomimetics and constrained peptides to modulate biological activity and improve metabolic stability.
• Ligand and Catalyst Development: Acts as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis.
• Agrochemical Synthesis: Intermediate in the production of advanced, stereospecific agrochemicals and plant growth regulators.
• Bioconjugation and Probe Chemistry: Useful in creating chemical probes and bioconjugates for biochemical and diagnostic applications due to its reactive carboxylic acid group.
• Academic and Industrial R&D: Serves as a standard or starting material in medicinal chemistry and organic synthesis research programs.

Basic Information

Product Name	4-Thiazolidinecarboxylicacid,5-Methyl-,(4R-Trans)-(9Ci)
CAS No.	72274-40-9
Molecular Formula	C5H9NO2S
Molecular Weight	147.20 g/mol
Synonyms	(4R)-5-Methyl-1,3-thiazolidine-4-carboxylic acid; (4R)-5-Methyl-4-thiazolidinecarboxylic acid; D-5-Methyl-4-thiazolidinecarboxylic acid; (R)-5-Methylthiazolidine-4-carboxylic acid; 5-Methyl-D-4-thiazolidinecarboxylic acid; (4R)-5-Methyl-thiazolidine-4-carboxylic acid; (R)-5-Methyl-1,3-thiazolidine-4-carboxylic acid; 72274-40-9
EINECS	Contact for details

Quality Control

Our 4-Thiazolidinecarboxylicacid,5-Methyl-,(4R-Trans)-(9Ci) is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, suitable for demanding synthetic applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, chiral purity, and impurity profiles. We support compliance with cGMP and ISO 9001 standards for pharmaceutical and fine chemical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Total impurities ≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.