Description

2,4-Difluorobenzylamine is a versatile fluorinated aromatic amine building block of significant importance in advanced organic synthesis. Its value lies in the unique reactivity and electronic properties imparted by the difluoro substitution pattern on the benzene ring, which is crucial for modulating the biological activity and physicochemical characteristics of target molecules. This intermediate is primarily needed by pharmaceutical, agrochemical, and material science research and development sectors for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, oncology, and anti-infective therapies.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, where the fluorine atoms enhance lipophilicity and metabolic stability.
• Ligand and Catalyst Preparation: Serves as a precursor for chiral auxiliaries and ligands in asymmetric catalysis, as well as for metal-organic frameworks (MOFs).
• Polymer and Material Science: Incorporated into monomers for the production of specialty polymers, resins, and advanced materials with tailored thermal and chemical resistance.
• Fluorescent Probe and Dye Manufacturing: Utilized in the synthesis of fluorophores and molecular probes for diagnostic and imaging applications.
• Peptidomimetic and Bio-conjugation Chemistry: The amine functionality allows for coupling reactions to create peptide analogs or for bioconjugation strategies in drug delivery systems.

Basic Information

Product Name	2,4-Difluorobenzylamine
CAS No.	72235-52-0
Molecular Formula	C7H7F2N
Molecular Weight	143.13 g/mol
Synonyms	(2,4-Difluorophenyl)methanamine; 2,4-Difluorobenzylamine; 1-(Aminomethyl)-2,4-difluorobenzene; Benzenemethanamine, 2,4-difluoro-; 2,4-Difluoro-α-toluidine; α-Amino-2,4-difluorotoluene; 2,4-DFBA
EINECS	Contact for details

Quality Control

Our 2,4-Difluorobenzylamine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chromatographic purity assays and identity confirmation, to ensure it meets the high standards required for research and commercial synthesis. Certificates of Analysis (COA) detailing purity, impurity profiles, and physical data are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and a strong base; containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen) to prevent degradation and moisture absorption. Keep away from strong acids and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms
Purity (GC/HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.