Description

[R,(-)]-3-o-Trityl-D-Glycerol 1-(p-Nitrobenzoate) is a high-purity, chiral synthetic intermediate of significant importance in advanced organic synthesis. This compound matters because it serves as a key building block for the preparation of complex, biologically active molecules, particularly in pharmaceutical research and development. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for the synthesis of enantiomerically pure target compounds.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the synthesis of active pharmaceutical ingredients (APIs), especially nucleoside analogs and other bioactive molecules.
• Asymmetric Synthesis: Used as a starting material or protected glycerol derivative in stereoselective reactions to construct complex molecular architectures.
• Nucleoside Chemistry: Serves as a protected precursor in the synthesis of modified nucleosides and nucleotides for antiviral or anticancer drug candidates.
• Glycoconjugate Research: Employed in the preparation of glycoconjugates and other carbohydrate-based compounds for biochemical studies.
• Ligand and Catalyst Development: Utilized as a scaffold for developing chiral ligands and organocatalysts used in enantioselective transformations.
• Academic & Industrial R&D: A valuable reagent for method development and exploratory research in synthetic organic chemistry laboratories worldwide.

Basic Information

Product Name	[R,(-)]-3-o-Trityl-D-Glycerol 1-(p-Nitrobenzoate)
CAS No.	72164-73-9
Molecular Formula	C29H25NO5
Molecular Weight	467.52 g/mol
Synonyms	(2R)-2-[(Triphenylmethoxy)methyl]oxirane-3-yl 4-nitrobenzoate; D-(-)-3-O-Tritylglycerol 1-p-Nitrobenzoate; (R)-(-)-3-O-Tritylglycidyl 4-Nitrobenzoate; (R)-Glycidyl 4-nitrobenzoate 3-trityl ether; 1,2-Epoxy-3-trityloxypropane 4-nitrobenzoate (R-enantiomer); (R)-3-O-Tritylglycidol 4-Nitrobenzoate; (R)-(-)-3-Trityloxy-1,2-epoxypropane 4-nitrobenzoate
EINECS	Contact for details

Quality Control

Our [R,(-)]-3-o-Trityl-D-Glycerol 1-(p-Nitrobenzoate) is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high chemical purity suitable for research and development applications. Certificates of Analysis (COA) detailing identity, purity (typically by HPLC or NMR), and specific impurity profiles are provided with each shipment. We adhere to cGMP principles where applicable to support our customers' regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound is light-sensitive; prolonged exposure to light should be avoided to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Optical Rotation [α]D20	Contact for details
Melting Point	Contact for details
Heavy Metals	< 10 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.