Description

2-Hydroxy-2-(Trifluoromethyl)Butyric Acid is a versatile fluorinated organic acid building block characterized by its unique combination of a hydroxyl group and a trifluoromethyl group on the same carbon atom. This structure is critical for modifying the physicochemical properties of target molecules, enhancing their metabolic stability, lipophilicity, and bioavailability. It is an essential intermediate for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for the synthesis of advanced active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing novel active pharmaceutical ingredients (APIs), especially those requiring fluorinated motifs for improved drug-like properties.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and pesticides where the trifluoromethyl group contributes to efficacy and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated compounds used in electronic displays and organic light-emitting diodes (OLEDs).
• Polymer Modification: Incorporated into specialty polymers to impart unique surface properties, chemical resistance, and durability.
• Complex Ligand Synthesis: Utilized in organometallic chemistry and catalysis for creating sophisticated chiral ligands and catalysts.
• Advanced Material Research: A valuable reagent in R&D for developing new fluorinated materials with specific optical or electronic characteristics.

Basic Information

Product Name	2-Hydroxy-2-(Trifluoromethyl)Butyric Acid
CAS No.	72114-82-0
Molecular Formula	C5H7F3O3
Molecular Weight	172.10 g/mol
Synonyms	2-(Trifluoromethyl)-2-hydroxybutyric Acid; α-Hydroxy-α-(trifluoromethyl)butyric Acid; 2-Hydroxy-2-trifluoromethylbutanoic Acid; 2-Trifluoromethyl-2-hydroxybutyric Acid; 2-Hydroxy-2-(trifluoromethyl)butanoic Acid; TFHBA; Butyric acid, 2-hydroxy-2-(trifluoromethyl)-
EINECS	Contact for details

Quality Control

Our 2-Hydroxy-2-(Trifluoromethyl)Butyric Acid is produced under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC, to ensure high purity and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment ensures the material meets the stringent requirements for research and cGMP manufacturing applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption. Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.