Description

2'-Chloro-5'-(Trifluoromethyl)Acetophenone is a high-purity, versatile organic intermediate characterized by its distinct aromatic ketone structure with chloro and trifluoromethyl substituents. This compound is valued for its role as a critical building block in the synthesis of more complex molecules, particularly in advanced pharmaceutical and agrochemical research. It is primarily sought after by R&D chemists and process development scientists in the fine chemical, pharmaceutical, and crop protection industries for constructing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially those targeting central nervous system (CNS) disorders and anti-inflammatory applications.
• Agrochemical Synthesis: Serves as a vital building block for developing novel herbicides, fungicides, and insecticides, leveraging the bioactivity of the trifluoromethyl group.
• Liquid Crystal & OLED Material Research: Used in the development of advanced electronic materials and organic light-emitting diodes (OLEDs) due to its aromatic and halogenated structure.
• Organic Synthesis & Catalysis: Employed as a substrate or ligand precursor in cross-coupling reactions and other catalytic processes in academic and industrial research laboratories.
• Fluorine Chemistry Studies: An important compound for investigating structure-activity relationships (SAR) and the effects of fluorine substitution in medicinal and material chemistry.

Basic Information

Product Name	2'-Chloro-5'-(Trifluoromethyl)Acetophenone
CAS No.	71648-45-8
Molecular Formula	C9H6ClF3O
Molecular Weight	222.59 g/mol
Synonyms	1-(2-Chloro-5-(trifluoromethyl)phenyl)ethan-1-one; 2-Chloro-α,α,α-trifluoro-p-acetophenone; 2-Chloro-5-(trifluoromethyl)acetophenone; 2-Chloro-α,α,α-trifluoro-4-methylacetophenone; 2'-Chloro-α,α,α-trifluoro-4'-methylacetophenone; 1-[2-Chloro-5-(trifluoromethyl)phenyl]ethanone; p-Methyl-2-chloro-α,α,α-trifluoroacetophenone
EINECS	Contact for details

Quality Control

Our 2'-Chloro-5'-(Trifluoromethyl)Acetophenone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment supports applications requiring high-purity intermediates for GMP and non-GMP synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong oxidizing agents, strong bases, and sources of ignition. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.