Description

6-Diazo-5-Oxo-D-Norleucine is a specialized diazoketone derivative of the non-proteinogenic amino acid D-norleucine. This compound serves as a valuable biochemical tool and synthetic intermediate due to its reactive diazo functional group, which can undergo various transformations under controlled conditions. It is primarily utilized by researchers and manufacturers in the fields of pharmaceutical development, proteomics, and advanced organic synthesis for creating novel molecular architectures and studying enzyme mechanisms.

Application

• Pharmaceutical Research & Development: Used as a key intermediate or precursor in the synthesis of novel drug candidates and biologically active molecules.
• Proteomics & Biochemical Studies: Acts as an affinity label or mechanism-based inhibitor for studying enzyme active sites, particularly those involving amino acid metabolism.
• Organic Synthesis: Serves as a versatile building block for carbon-carbon bond formation reactions, such as Wolff rearrangement and cyclopropanation, leveraging its reactive diazo group.
• Peptide Modification: Employed for the site-specific modification of peptides and proteins to introduce ketone or other functional handles for conjugation.
• Academic Research: Utilized in university and institutional labs for fundamental research in bioorganic chemistry and medicinal chemistry.
• Cross-linking Agent Development: Investigated for the development of novel photoaffinity or chemical cross-linkers for structural biology applications.

Basic Information

Product Name	6-Diazo-5-Oxo-D-Norleucine
CAS No.	71629-86-2
Molecular Formula	C7H11N3O3
Molecular Weight	185.18 g/mol
Synonyms	DON; 6-Diazo-5-oxonorleucine; Diazooxonorleucine; (2R)-2-Amino-6-diazo-5-oxohexanoic acid; D-6-Diazo-5-oxo-norleucine; Azotomycin component; NSC 7365; Antibiotic U-9889
EINECS	Contact for details

Quality Control

Our 6-Diazo-5-Oxo-D-Norleucine is produced and handled under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity assessment, NMR and IR for structural confirmation, and chiral analysis to ensure stereochemical integrity. Certificates of Analysis (COA) detailing all specifications are provided to guarantee consistent quality and traceability for your research and production needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C or below under an inert atmosphere for long-term stability. The material is light-sensitive and should be handled under subdued lighting. Allow the sealed container to reach room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Chiral Purity (HPLC)	≥ 98% D-isomer
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.