Description

1H-Pyrrole, 3-(Trifluoromethyl)- is a high-value, fluorinated heterocyclic building block of significant interest in advanced organic synthesis. Its core value lies in the unique electronic and steric properties imparted by the trifluoromethyl group attached to the pyrrole ring, making it a critical intermediate for developing novel compounds with enhanced biological activity and material properties. This compound is essential for research and development chemists and process engineers working in the pharmaceutical, agrochemical, and specialty materials sectors. Its CAS number is 71580-26-2.

Application

The 3-(trifluoromethyl)pyrrole scaffold is a versatile precursor in the synthesis of complex molecules. Key application areas include:

• Pharmaceutical Intermediates: Serves as a core building block for the development of active pharmaceutical ingredients (APIs), particularly in drug discovery programs targeting central nervous system (CNS) disorders, anti-infectives, and oncology.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the CF3 group often improves metabolic stability and lipophilicity.
• Material Science & Organic Electronics: Acts as a monomer or dopant in the synthesis of conductive polymers, organic semiconductors, and non-linear optical (NLO) materials.
• Ligand & Catalyst Development: Employed to create novel nitrogen-containing ligands for transition metal catalysis, enabling more efficient and selective chemical transformations.
• Fluorine Chemistry Research: A valuable substrate for studying the introduction and reactivity of fluorinated groups in heterocyclic systems.

Basic Information

Product Name	1H-Pyrrole, 3-(Trifluoromethyl)-
CAS No.	71580-26-2
Molecular Formula	C5H4F3N
Molecular Weight	135.09 g/mol
Synonyms	3-(Trifluoromethyl)-1H-pyrrole; 3-(Trifluoromethyl)pyrrole; 3-Trifluoromethylpyrrole; 1H-Pyrrole, 3-(trifluoromethyl)-; α,α,α-Trifluoro-3-pyrroline; 3-CF3-Pyrrole
EINECS	Contact for details

Quality Control

Our 1H-Pyrrole, 3-(Trifluoromethyl)- is produced under strict quality management protocols. Every batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure high purity and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing identity, assay, and impurity profiles to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.