Description

Verrucarin I is a potent macrocyclic trichothecene mycotoxin produced by various fungal species. This compound is of significant interest in biochemical and pharmacological research due to its potent biological activity, particularly as a protein synthesis inhibitor. It serves as a critical reference standard and research tool for scientists in toxicology, mycology, and drug discovery. Global suppliers and research institutions rely on high-purity Verrucarin I for method development, contamination analysis, and mechanistic studies.

Application

• Analytical Reference Standard: Primary use as a certified standard for the accurate quantification and identification of trichothecene mycotoxins in food, feed, and environmental samples via HPLC, LC-MS/MS.
• Biochemical Research: Investigation of protein synthesis inhibition mechanisms, cellular toxicity pathways, and ribosome function in eukaryotic cells.
• Toxicology Studies: Used in in vitro and in vivo studies to understand the toxicological profile, dose-response relationships, and health impacts of trichothecene exposure.
• Mycotoxin Contamination Control: Essential for developing and validating detection methods to ensure food safety and regulatory compliance in agricultural and food production industries.
• Pharmaceutical Research: Serves as a lead compound or tool molecule in exploring potential therapeutic agents, particularly in oncology research targeting protein synthesis.
• Quality Control & Method Development: Used by testing laboratories and manufacturers to calibrate equipment and establish validated analytical procedures.

Basic Information

Product Name	Verrucarin I
CAS No.	71427-24-2
Molecular Formula	C₂₇H₃₄O₉
Molecular Weight	502.56 g/mol
Synonyms	Verrucarin A; NSC 169435; 4β,15-Diacetoxy-12,13-epoxy-3α,7α-dihydroxy-9,10-dimethyl-1,11(12)-trichothecadiene-8-one; (-)-Verrucarin A; Trichothecene Verrucarin A; 12,13-Epoxytrichothec-9-ene-3,4,7,8,15-pentol 4,15-diacetate 8-(2-methyl-2-butenoate); Roridin L-2
EINECS	Contact for details

Quality Control

Every batch of Verrucarin I is produced and analyzed under strict quality management protocols to ensure identity, purity, and consistency. Our quality control includes comprehensive chromatographic analysis (HPLC, TLC) and spectroscopic confirmation (NMR, MS). A detailed Certificate of Analysis (COA) is provided with each shipment, documenting the purity, assay results, and any specified impurity profiles to meet the stringent requirements of research and analytical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere in a freezer (-20°C).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (IR)	Spectrum matches reference spectrum
Purity (HPLC)	≥ 95.0%
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.