Description

2-Aminocyclobutan-1-Ol is a versatile chiral building block featuring both amino and hydroxyl functional groups on a strained four-membered cyclobutane ring. This unique structure makes it a valuable intermediate for the synthesis of complex pharmaceutical compounds and advanced materials. It is particularly sought after by research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing novel molecular architectures with potential biological activity.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the development of novel active pharmaceutical ingredients (APIs), especially in antiviral, anticancer, and central nervous system (CNS) drug candidates.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides that require specific stereochemistry for efficacy.
• Ligand and Catalyst Preparation: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis to control stereoselectivity.
• Peptidomimetics and Bioactive Molecule Design: The aminocyclobutanol scaffold is incorporated into peptide analogs and other bioactive molecules to modulate stability, conformation, and receptor binding.
• Material Science Research: Investigated as a monomer or cross-linking agent for producing polymers with unique thermal or mechanical properties.
• Chemical Biology Probes: Utilized in the synthesis of molecular probes for studying enzyme mechanisms and biological pathways.

Basic Information

Product Name	2-Aminocyclobutan-1-Ol
CAS No.	71347-12-1
Molecular Formula	C4H9NO
Molecular Weight	87.12 g/mol
Synonyms	2-Aminocyclobutanol; 1-Aminocyclobutane-2-ol; 2-Aminocyclobutyl alcohol; cis/trans-2-Aminocyclobutan-1-ol; (±)-2-Aminocyclobutan-1-ol; Aminocyclobutanol; Cyclobutanol, 2-amino-; 2-Hydroxycyclobutanamine
EINECS	Contact for details

Quality Control

Our 2-Aminocyclobutan-1-Ol is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including chiral purity analysis, to ensure it meets the high standards required for research and development. A detailed Certificate of Analysis (COA) providing specifications for identity, purity (by HPLC), enantiomeric excess, and related substances is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	Specify required isomer (Contact for details)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.