Description

n-Trifluoroacetyl-n-Methyl-Deacetylcolchicine is a chemically modified derivative of the natural alkaloid colchicine, designed for advanced research and pharmaceutical development. This compound is valued for its role as a key synthetic intermediate and a potent biochemical tool in the study of tubulin dynamics and anti-mitotic mechanisms. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and life sciences sectors for drug discovery, process chemistry, and the development of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of novel colchicine analogs and other bioactive molecules for therapeutic development.
• Biochemical Research: Used as a reference standard and a potent probe in cell biology studies to investigate microtubule assembly, mitosis, and cell cycle regulation.
• Drug Discovery: Employed in high-throughput screening and structure-activity relationship (SAR) studies to identify and optimize new anti-cancer and anti-inflammatory drug candidates.
• Process Chemistry: Acts as a key intermediate in the scale-up and optimization of synthetic routes for complex alkaloid-based active pharmaceutical ingredients (APIs).
• Academic Research: Utilized in university and institutional laboratories for fundamental research in medicinal chemistry, pharmacology, and chemical biology.

Basic Information

Product Name	n-Trifluoroacetyl-n-Methyl-Deacetylcolchicine
CAS No.	71295-35-7
Molecular Formula	C23H24F3NO5
Molecular Weight	451.44 g/mol
Synonyms	N-Trifluoroacetyl-N-methyl-deacetylcolchicine; N-Methyl-N-trifluoroacetyldeacetylcolchicine; Deacetylcolchicine N-methyl-N-trifluoroacetate; Colchicine derivative (trifluoroacetyl, methyl); 7-Acetamido-6,7-dihydro-1,2,3,10-tetramethoxy-N-methyl-N-(trifluoroacetyl)-benzo[a]heptalen-9(5H)-one
EINECS	Contact for details

Quality Control

Our n-Trifluoroacetyl-n-Methyl-Deacetylcolchicine is produced under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and development. Each lot undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to guarantee compliance with your research-grade requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container should be kept in a desiccated environment. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.