Description

n-Trifluoroacetyl Deacetylcolchiceine is a key trifluoroacetylated derivative of the colchicine alkaloid family, serving as a critical synthetic intermediate and reference standard. Its value lies in enabling precise chemical modifications and analytical studies within complex natural product research. This compound is primarily needed by pharmaceutical R&D laboratories, academic research institutions, and fine chemical manufacturers focused on developing novel therapeutic agents and conducting advanced biochemical studies.

Application

• Pharmaceutical Intermediate: A crucial building block in the semi-synthesis and structural modification of colchicine analogs and related bioactive molecules.
• Reference Standard: Used as a high-purity analytical standard for method development, validation, and quality control in pharmaceutical analysis.
• Biochemical Research: Employed in studies investigating tubulin binding, anti-mitotic activity, and the structure-activity relationships (SAR) of colchicinoids.
• Medicinal Chemistry: Serves as a versatile scaffold for the design and synthesis of new chemical entities with potential anti-inflammatory, anti-gout, or anti-cancer properties.
• Process Chemistry: Utilized in route scouting and optimization for the scalable production of colchicine-derived active pharmaceutical ingredients (APIs).

Basic Information

Product Name	n-Trifluoroacetyl Deacetylcolchiceine
CAS No.	71295-34-6
Molecular Formula	C22H22F3NO6
Molecular Weight	453.41 g/mol
Synonyms	N-Trifluoroacetyldeacetylcolchicine; Deacetylcolchicine Trifluoroacetate; Colchiceine, N-trifluoroacetyl-; 3-[(7S)-1,2,3,10-Tetramethoxy-9-oxo-5,6,7,9-tetrahydrobenzo[a]heptalen-7-yl]amino-3-oxopropyl trifluoroacetate; N-[(7S)-1,2,3,10-Tetramethoxy-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl]-2,2,2-trifluoroacetamide; Trifluoroacetylcolchiceine; F3C-CO-Colchiceine
EINECS	Contact for details

Quality Control

Our n-Trifluoroacetyl Deacetylcolchiceine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods (NMR, MS), to ensure it meets exacting standards for research and development use. Certificates of Analysis (COA) with detailed chromatographic and spectral data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment to prevent moisture absorption. Handle and store in accordance with good laboratory practices.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.