Description

2-(2,2,2-Trifluoro-1-Phenylethoxy)Butyric Acid is a specialized fluorinated organic acid ester, identified by CAS NO 71074-91-4, that serves as a key chiral intermediate in advanced synthetic chemistry. Its molecular structure, featuring a trifluoromethyl group and a phenyl ring, is engineered to introduce specific steric and electronic properties into target molecules. This compound is primarily utilized by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients, where its unique fluorinated scaffold is critical for modulating biological activity and metabolic stability.

Application

• Pharmaceutical Intermediate: A crucial chiral building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in developing central nervous system (CNS) and anti-inflammatory drugs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides and pesticides, where the trifluoromethyl group enhances lipophilicity and biological efficacy.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Employed in the development of fluorinated polymers and specialty chemicals with unique surface properties and stability.
• Custom Synthesis & Contract Manufacturing: A key starting material for custom synthesis projects and contract research organizations (CROs/CMOs) working on proprietary fluorinated compounds.

Basic Information

Product Name	2-(2,2,2-Trifluoro-1-Phenylethoxy)Butyric Acid
CAS No.	71074-91-4
Molecular Formula	C12H13F3O3
Molecular Weight	262.22 g/mol
Synonyms	2-[(2,2,2-Trifluoro-1-phenylethoxy)]butanoic acid; Butanoic acid, 2-[(2,2,2-trifluoro-1-phenylethoxy)]-; α-(2,2,2-Trifluoro-1-phenylethoxy)butyric acid; (RS)-2-[(2,2,2-Trifluoro-1-phenylethoxy)]butyric acid; TFPEBA; 2-(2,2,2-Trifluoro-1-phenylethoxy)butanoic acid
EINECS	Contact for details

Quality Control

Our production of 2-(2,2,2-Trifluoro-1-Phenylethoxy)Butyric Acid adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. Each lot is analyzed using advanced chromatographic and spectroscopic techniques. Certificates of Analysis (COA) detailing purity, chiral purity (enantiomeric excess), and impurity profiles are provided with every shipment. We support development and commercial projects with specifications tailored to meet cGMP and other relevant regulatory guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% e.e. (or as specified)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.