Description

4'-Phenoxy-2,2,2-Trifluoroacetophenone is a high-value trifluoromethyl ketone derivative, a key building block in advanced organic synthesis. Its structure makes it a versatile intermediate for introducing the phenoxy and trifluoroacetyl functional groups into target molecules. This compound is particularly sought after by research and development teams in the pharmaceutical and agrochemical sectors. It enables the synthesis of novel compounds with potential biological activity.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of active pharmaceutical ingredients (APIs), especially those requiring trifluoromethyl motifs for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group can improve efficacy and environmental profile.
• Liquid Crystal Materials: Serves as a key intermediate for the development of fluorine-containing liquid crystals used in display technologies.
• Organic Electronics: Employed in the synthesis of novel organic semiconductors and charge-transport materials due to its electron-withdrawing properties.
• Chemical Research & Development: A valuable reagent for medicinal chemistry, process chemistry, and material science research programs exploring new molecular entities.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs and fine chemical companies for use in bespoke synthesis projects for clients.

Basic Information

Product Name	4'-Phenoxy-2,2,2-Trifluoroacetophenone
CAS No.	70783-32-3
Molecular Formula	C14H9F3O2
Molecular Weight	266.22 g/mol
Synonyms	1-[4-(Phenoxy)phenyl]-2,2,2-trifluoroethanone; 2,2,2-Trifluoro-1-(4-phenoxyphenyl)ethanone; 4-Phenoxy-α,α,α-trifluoroacetophenone; p-Phenoxy-α,α,α-trifluoroacetophenone; 4-Phenoxyphenyl trifluoromethyl ketone; Phenoxytrifluoroacetophenone; TFAP-OPh
EINECS	Contact for details

Quality Control

Every batch of 4'-Phenoxy-2,2,2-Trifluoroacetophenone is produced and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the precise requirements of your synthesis. A detailed Certificate of Analysis (COA) is supplied with each shipment, confirming identity, purity, and impurity profiles as determined by advanced chromatographic and spectroscopic methods.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from strong bases and reducing agents. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.