Description

trans-2-(4-Fluoro-Phenyl)-Cyclopropanecarboxylic Acid Ethyl Ester is a high-value fluorinated cyclopropane derivative, serving as a critical chiral building block in advanced organic synthesis. Its unique structural motif, combining a cyclopropane ring with a fluorinated aromatic system, is essential for modulating the biological activity and physicochemical properties of target molecules. This intermediate is primarily sought after by pharmaceutical and agrochemical research organizations for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new drug candidates, particularly in central nervous system (CNS) and anti-infective therapeutic areas.
• Agrochemical Synthesis: Used in the production of advanced pesticides and herbicides, where the fluorinated cyclopropane structure can enhance stability and efficacy.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Employed in the synthesis of novel fluorinated polymers or liquid crystals with specific optical or electronic properties.
• Chemical Biology Probes: Utilized as a building block for fluorescent tags or molecular probes to study biological processes.

Basic Information

Product Name	trans-2-(4-Fluoro-Phenyl)-Cyclopropanecarboxylic Acid Ethyl Ester
CAS No.	70461-58-4
Molecular Formula	C₁₂H₁₃FO₂
Molecular Weight	208.23 g/mol
Synonyms	Ethyl trans-2-(4-fluorophenyl)cyclopropanecarboxylate; trans-2-(p-Fluorophenyl)cyclopropanecarboxylic Acid Ethyl Ester; 2-(4-Fluorophenyl)cyclopropanecarboxylic Acid Ethyl Ester, trans-; Ethyl (1R,2S)-2-(4-fluorophenyl)cyclopropanecarboxylate (enantiomer); Ethyl (1S,2R)-2-(4-fluorophenyl)cyclopropanecarboxylate (enantiomer); 4-Fluorophenylcyclopropanecarboxylic Acid Ethyl Ester; F-CPP Ester
EINECS	Contact for details

Quality Control

Our trans-2-(4-Fluoro-Phenyl)-Cyclopropanecarboxylic Acid Ethyl Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity analysis, to ensure it meets the exacting standards required for pharmaceutical and fine chemical applications. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flames. For long-term storage, consider an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee (trans-isomer)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.