Description

3-Fluoro-3-Nitrooxetane is a high-value, functionalized oxetane building block of significant interest in advanced organic synthesis. Its unique structure, featuring both fluorine and nitro substituents on a strained four-membered oxetane ring, makes it a versatile precursor for the development of novel pharmaceuticals, agrochemicals, and energetic materials. This compound is particularly sought after by research and development chemists in the pharmaceutical and specialty chemical industries for constructing complex molecular architectures and introducing key functional groups.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of novel active pharmaceutical ingredients (APIs), especially in medicinal chemistry programs targeting new therapeutic agents.
• Agrochemical Research: Used in the development of next-generation herbicides, fungicides, and insecticides, leveraging the bioactivity of both the fluorine and nitro groups.
• Energetic Materials Precursor: Serves as a building block in the research and formulation of advanced, high-performance energetic compounds and propellants.
• Polymer Modification: Employed to introduce fluorinated and nitro-functionalized side chains into polymers, altering their physical, chemical, or energetic properties.
• Ligand and Catalyst Development: Utilized in organometallic chemistry to create novel ligands and catalysts with tailored electronic and steric properties.
• Cross-Coupling Reactions: Acts as an electrophilic partner in various metal-catalyzed cross-coupling reactions to form carbon-carbon bonds.

Basic Information

Item	Detail
Product Name	3-Fluoro-3-Nitrooxetane
CAS No.	70187-44-9
Molecular Formula	C3H4FNO3
Molecular Weight	121.07 g/mol
Synonyms	3-Fluoro-3-nitrooxetane; 3-Fluoro-3-nitrooxacyclobutane; 3-Fluoro-3-nitro-1-oxacyclobutane; 3-Nitro-3-fluorooxetane; Oxetane, 3-fluoro-3-nitro-; 1-Oxa-2-fluoranyl-2-nitrocyclobutane
EINECS	Contact for details

Quality Control

Our 3-Fluoro-3-Nitrooxetane is produced and handled under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including NMR (¹H, ¹³C, ¹⁹F), HPLC, and GC analysis, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, documenting all critical quality parameters. Our commitment to cGMP principles and adherence to ISO 9001 standards underpin our reliable supply chain for research and development purposes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (15-25°C). This compound is easily oxidized and should be stored under an inert atmosphere (e.g., nitrogen or argon) for long-term stability. Keep away from heat, sparks, open flames, and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (NMR)	Conforms to structure
Purity (HPLC/GC)	≥ 95.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.