Description

12-o-2Z-4E-Octadienoyl-4-Deoxyphorbol-13-Acetate is a highly specific diterpene ester derivative of phorbol, a compound of significant interest in biochemical and pharmacological research. This molecule serves as a critical reference standard and a potent, selective tool compound for studying protein kinase C (PKC) signaling pathways and related cellular mechanisms. It is primarily utilized by research institutions, pharmaceutical R&D departments, and biotechnology companies engaged in cancer research, inflammation studies, and the development of novel therapeutic agents targeting PKC isoforms.

Application

• Biochemical Research: As a high-purity reference standard for analytical method development and validation in HPLC, LC-MS, and NMR studies.
• Pharmacology & Drug Discovery: A key tool compound for investigating the activation, inhibition, and downstream effects of Protein Kinase C (PKC) enzymes in cellular models.
• Cancer Research: Used in studies exploring the role of PKC in tumor promotion, cell proliferation, and apoptosis, aiding in the identification of new oncology targets.
• Signal Transduction Studies: Essential for elucidating complex intracellular signaling cascades involving diacylglycerol (DAG) analogs and their receptors.
• Toxicology & Safety Assessment: Employed as a calibrated agonist in assays designed to understand the mechanistic toxicity of phorbol-related compounds.
• Academic Research: Supports fundamental research in molecular biology, cell biology, and medicinal chemistry at universities and government labs.

Basic Information

Product Name	12-o-2Z-4E-Octadienoyl-4-Deoxyphorbol-13-Acetate
CAS No.	70028-76-1
Molecular Formula	C36H48O8
Molecular Weight	608.77 g/mol
Synonyms	4-Deoxy-12-O-(2Z,4E-octadienoyl)phorbol 13-acetate; 12-O-(2Z,4E-Octadienoyl)-4-deoxyphorbol-13-acetate; 4-Deoxyphorbol 13-acetate 12-(2Z,4E-octadienoate); DOPA 12-tiglinate; A specific phorbol ester derivative; PKC activator analog; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our 12-o-2Z-4E-Octadienoyl-4-Deoxyphorbol-13-Acetate is produced and handled under strict quality management protocols to ensure batch-to-batch consistency and high purity, essential for reliable research outcomes. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We support research-grade specifications and can provide material tailored to specific project requirements upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere for long-term stability. Allow the sealed container to reach room temperature before opening to prevent condensation. Keep away from oxidizing agents and strong bases.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.