Description

(4R)-4-(2-Hydroxyethyl)-2,2-Dimethyl-1,3-Dioxolane is a chiral 1,3-dioxolane derivative, a versatile protected form of a vicinal diol or hydroxyaldehyde. This compound is a crucial chiral building block and protecting group reagent in sophisticated organic synthesis, offering high stereochemical purity and stability under a wide range of reaction conditions. It is primarily sought after by research and development chemists in the pharmaceutical, agrochemical, and fine chemical industries for the synthesis of complex, optically active molecules.

Application

• Chiral Intermediate in Pharmaceutical Synthesis: A key precursor for the production of active pharmaceutical ingredients (APIs) requiring specific stereochemistry, such as certain antiviral or cardiovascular drugs.
• Agrochemical Intermediate: Used in the synthesis of enantiomerically pure herbicides, fungicides, and plant growth regulators where biological activity is stereospecific.
• Fine Chemical and Fragrance Synthesis: Serves as a chiral synthon for creating complex aroma chemicals and other high-value specialty chemicals.
• Asymmetric Catalysis Ligand Precursor: Can be utilized to develop novel chiral ligands for asymmetric hydrogenation and other catalytic transformations.
• Polymer Chemistry: Acts as a monomer or co-monomer for creating polymers with specific chiral centers or functional groups.
• Academic and Industrial R&D: A valuable reagent for methodological development in organic chemistry and for exploring new synthetic pathways.

Basic Information

Item	Details
Product Name	(4R)-4-(2-Hydroxyethyl)-2,2-Dimethyl-1,3-Dioxolane
CAS No.	70005-89-9
Molecular Formula	C7H14O3
Molecular Weight	146.18 g/mol
Synonyms	(R)-4-(2-Hydroxyethyl)-2,2-dimethyl-1,3-dioxolane; (4R)-2,2-Dimethyl-4-(2-hydroxyethyl)-1,3-dioxolane; (R)-(-)-2,2-Dimethyl-4-(2-hydroxyethyl)-1,3-dioxolane; (R)-1,2-Isopropylidenedioxy-4-butanol; (R)-1,2-O-Isopropylidene-4-hydroxybutane-1,2-diol; D-(+)-Pantolactone acetonide (related derivative); (R)-Glycerol Acetonide 2-Ethanol
EINECS	Contact for details

Quality Control

Our (4R)-4-(2-Hydroxyethyl)-2,2-Dimethyl-1,3-Dioxolane is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity analysis by HPLC or GC, to ensure high enantiomeric excess (e.e.) and chemical purity suitable for demanding synthetic applications. Certificates of Analysis (COA) detailing identity, purity, and specific impurities are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC/GC)	≥ 98.0% e.e.
Specific Rotation [α]D20	Contact for details
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.