Description

(S)-2-(Trimethylsilylamino)-3-(Trimethylsilyloxy)Propanoic Acid Trimethylsilyl Ester is a highly functionalized, silyl-protected derivative of serine, designed for advanced synthetic applications. This compound is critical for providing exceptional protection of amino and carboxyl groups during complex, multi-step organic syntheses, particularly where anhydrous conditions are paramount. It is an essential building block for researchers and manufacturers in pharmaceutical development, enabling the synthesis of peptides, chiral intermediates, and other bioactive molecules.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of complex drug candidates, including protease inhibitors and other biologically active compounds.
• Peptide Chemistry: Used in the preparation of protected serine derivatives for solid-phase and solution-phase peptide synthesis.
• Asymmetric Synthesis: Serves as a versatile starting material or intermediate in catalytic asymmetric reactions to construct stereogenic centers.
• Organosilicon Chemistry: Employed in reactions exploring silyl group transfer or as a model compound for studying silyl protection/deprotection strategies.
• Chemical Research & Development: A valuable reagent for academic and industrial R&D labs focusing on novel synthetic methodologies and protecting group chemistry.
• Agrochemical Synthesis: Potential intermediate in the production of chiral, high-value crop protection agents.

Basic Information

Product Name	(S)-2-(Trimethylsilylamino)-3-(Trimethylsilyloxy)Propanoic Acid Trimethylsilyl Ester
CAS No.	7364-48-9
Molecular Formula	C12H29NO3Si3
Molecular Weight	319.62 g/mol
Synonyms	L-Serine, N-(trimethylsilyl)-, 3-(trimethylsilyloxy)-, trimethylsilyl ester; (S)-2-((Trimethylsilyl)amino)-3-((trimethylsilyl)oxy)propanoic acid trimethylsilyl ester; N,O-Bis(trimethylsilyl)-L-serine trimethylsilyl ester; Serine, N,3-bis(trimethylsilyl)-, trimethylsilyl ester, L-; L-Serine, N-(trimethylsilyl)-3-(trimethylsilyloxy)-, trimethylsilyl ester; 7364-48-9; Tris(trimethylsilyl)-L-serinate
EINECS	Contact for details

Quality Control

Our production of (S)-2-(Trimethylsilylamino)-3-(Trimethylsilyloxy)Propanoic Acid Trimethylsilyl Ester adheres to stringent quality protocols suitable for research and pharmaceutical intermediate applications. Every batch undergoes comprehensive analysis including HPLC for chiral purity and assay, NMR for structural confirmation, and Karl Fischer titration for moisture content. A detailed Certificate of Analysis (COA) is provided with each shipment to ensure traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent degradation. Keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Chiral Purity (HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.