Description

Z-Pro-Pro-Oh CAS NO 7360-23-8 is a high-purity, protected dipeptide derivative, specifically the benzyl ester of the Z-protected prolyl-proline dipeptide. This compound is a critical building block in advanced peptide synthesis, offering precise control over molecular structure and sequence. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of novel therapeutic peptides, protease inhibitors, and biochemical probes.

Application

• Pharmaceutical Intermediate: Serves as a key synthon in the solid-phase and solution-phase synthesis of complex peptide-based drugs and candidates.
• Protease Inhibitor Research: Used in the design and development of inhibitors targeting proline-specific enzymes like dipeptidyl peptidase IV (DPP-IV).
• Biochemical Tool Compound: Employed in enzymatic studies and as a standard in analytical method development for peptide chemistry.
• Academic & Industrial R&D: A fundamental reagent for exploring peptide conformation, stability, and structure-activity relationships (SAR).
• Custom Peptide Synthesis: Provides a protected proline-proline sequence unit for bespoke peptide manufacturing services.

Basic Information

Product Name	Z-Pro-Pro-Oh
CAS No.	7360-23-8
Molecular Formula	C24H26N2O5
Molecular Weight	422.48 g/mol
Synonyms	Z-Pro-Pro-OBzl; Benzyl N-[(benzyloxy)carbonyl]-L-prolyl-L-prolinate; CBZ-L-Prolyl-L-Proline Benzyl Ester; N-Carbobenzoxy-L-prolyl-L-proline benzyl ester; Z-L-Pro-L-Pro-OBzl; (S)-Benzyl 1-((S)-1-((benzyloxy)carbonyl)pyrrolidine-2-carbonyl)pyrrolidine-2-carboxylate; L-Proline, N-[(phenylmethoxy)carbonyl]-, 1-(phenylmethyl) ester, (S)-
EINECS	Contact for details

Quality Control

Our Z-Pro-Pro-Oh is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and identity confirmation via IR and NMR spectroscopy. We provide full traceability and Certificates of Analysis (COA) are available for all shipments, ensuring compliance with research and cGMP starting material standards where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.