Description

4-Chloro-2-(Chloromethyl)-1-Methoxybenzene is a versatile halogenated aromatic building block of significant importance in advanced organic synthesis. Its bifunctional structure, featuring both a chloro and a chloromethyl substituent on a methoxybenzene core, makes it a critical intermediate for constructing complex molecular architectures. This compound is primarily sought after by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of active ingredients and specialty chemicals.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those with benzyl ether or substituted benzylamine motifs.
• Agrochemical Synthesis: Used in the manufacture of herbicides, fungicides, and insecticides, where the chloromethyl group allows for further functionalization.
• Ligand and Catalyst Preparation: Serves as a starting material for synthesizing specialized ligands used in homogeneous catalysis and metal-organic frameworks (MOFs).
• Polymer Chemistry: Acts as a monomer or cross-linking agent in the production of specialty polymers and resins with specific thermal or chemical resistance properties.
• Dye and Pigment Manufacturing: Intermediate in the synthesis of complex organic dyes and pigments, contributing to color fastness and molecular stability.
• Chemical Research & Development: A valuable scaffold in medicinal chemistry for structure-activity relationship (SAR) studies and library synthesis.

Basic Information

Product Name	4-Chloro-2-(Chloromethyl)-1-Methoxybenzene
CAS No.	7035-11-2
Molecular Formula	C8H8Cl2O
Molecular Weight	191.06 g/mol
Synonyms	2-Chloromethyl-4-chloroanisole; 4-Chloro-2-(chloromethyl)anisole; 1-Chloro-4-methoxy-2-(chloromethyl)benzene; 2,4-Dichlorobenzyl Methyl Ether; Benzene, 4-chloro-2-(chloromethyl)-1-methoxy-; 4-Chloro-2-chloromethyl-1-methoxybenzene; 2-(Chloromethyl)-4-chloroanisole
EINECS	Contact for details

Quality Control

Our 4-Chloro-2-(Chloromethyl)-1-Methoxybenzene is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles where applicable, ensuring reliability for your critical synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong bases and oxidizing agents. The compound may be light-sensitive; prolonged exposure to light should be avoided.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 0.5% Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.