Description

2-Chloro-5-(Trifluoromethylsulfonyl)Aniline is a high-value, multi-functional aromatic amine building block distinguished by its unique combination of chloro and trifluoromethanesulfonyl substituents. This compound is essential for synthesizing advanced molecules where electronic modulation and enhanced lipophilicity are required. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for creating novel active ingredients and intermediates.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in kinase inhibitor and anti-inflammatory drug discovery programs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, leveraging its bioisosteric properties.
• Material Science Research: Serves as a precursor for specialty polymers, liquid crystals, and organic electronic materials due to its electron-withdrawing groups.
• Dye and Pigment Intermediate: Employed in the synthesis of specialized dyes and pigments where the sulfonyl and fluorine groups alter color fastness and solubility.
• Cross-Coupling Reactions: Acts as a valuable substrate in palladium-catalyzed cross-coupling reactions (e.g., Buchwald-Hartwig amination) for constructing complex aromatic systems.

Basic Information

Product Name	2-Chloro-5-(Trifluoromethylsulfonyl)Aniline
CAS No.	779-87-3
Molecular Formula	C7H5ClF3NO2S
Molecular Weight	259.63 g/mol
Synonyms	2-Chloro-5-(trifluoromethylsulfonyl)benzenamine; 2-Chloro-α,α,α-trifluoro-p-toluenesulfonanilide; 5-Amino-2-chlorophenyl trifluoromethyl sulfone; 2-Chloro-5-aminophenyl trifluoromethyl sulfone; Benzenamine, 2-chloro-5-[(trifluoromethyl)sulfonyl]-; 2-Chloro-5-trifluoromethanesulfonylaniline
EINECS	Contact for details

Quality Control

Every batch of 2-Chloro-5-(Trifluoromethylsulfonyl)Aniline is manufactured and tested under a strict quality management system. We guarantee high chemical purity and consistency to meet the exacting standards of fine chemical synthesis. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles by HPLC, GC, and NMR is provided with each shipment to ensure traceability and support your regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong bases and oxidizing agents. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.