Description

2-Nitro-4-(Trifluoromethyl)Benzonitrile is a high-purity, versatile aromatic nitrile building block characterized by its nitro and trifluoromethyl substituents. This compound is valued for its role as a critical intermediate in the synthesis of advanced agrochemicals and active pharmaceutical ingredients (APIs), where its unique structure imparts desirable biological and physicochemical properties. It is primarily sought after by R&D laboratories and production facilities in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecular architectures.

Application

• Agrochemical Intermediate: A key precursor in the synthesis of modern herbicides and pesticides, leveraging the bioactivity of the trifluoromethyl and nitro groups.
• Pharmaceutical Building Block: Used in medicinal chemistry for the development of novel drug candidates, particularly in areas requiring fluorinated motifs for enhanced metabolic stability and bioavailability.
• Material Science Research: Serves as a monomer or functionalizing agent in the development of specialty polymers and advanced organic materials.
• Dye and Pigment Synthesis: Employed in the production of specialized colorants and functional dyes due to its electron-withdrawing substituents.
• Ligand and Catalyst Development: Utilized in organometallic chemistry to create novel ligands for catalytic processes.
• Cross-Coupling Reactions: Acts as a substrate in palladium-catalyzed reactions, such as Suzuki or Buchwald-Hartwig couplings, for carbon-carbon and carbon-heteroatom bond formation.

Basic Information

Product Name	2-Nitro-4-(Trifluoromethyl)Benzonitrile
CAS No.	778-94-9
Molecular Formula	C8H3F3N2O2
Molecular Weight	216.12 g/mol
Synonyms	4-(Trifluoromethyl)-2-nitrobenzonitrile; 2-Nitro-α,α,α-trifluoro-p-toluonitrile; Benzonitrile, 2-nitro-4-(trifluoromethyl)-; 2-Nitro-4-trifluoromethylbenzonitrile; 4-Cyano-3-nitrobenzotrifluoride; 3-Nitro-4-cyanobenzotrifluoride; p-Cyanobenzotrifluoride, 3-nitro-; 778-94-9
EINECS	212-307-5

Quality Control

Our 2-Nitro-4-(Trifluoromethyl)Benzonitrile is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and FTIR, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, confirming compliance with customer specifications and relevant industry standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong bases and reducing agents. The container should be kept tightly sealed in a dry environment to minimize moisture exposure.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	92 - 96 °C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.