Description

1-Bromo-2-Ethynylbenzene is a versatile aromatic building block featuring both a bromine substituent and an ethynyl (acetylene) group on the benzene ring. This bifunctional structure makes it a critical intermediate for constructing complex molecules via cross-coupling and cycloaddition reactions. It is primarily sought after by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for the synthesis of novel active ingredients and functional polymers.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for compounds requiring a substituted phenylacetylene scaffold.
• Agrochemical Synthesis: Used in the development of new herbicides, fungicides, and insecticides where the ethynylbenzene moiety is integral to biological activity.
• Material Science: Serves as a monomer or cross-linking agent in the production of specialty polymers, dendrimers, and conductive organic materials.
• Ligand & Catalyst Development: Employed in the creation of novel phosphine or N-heterocyclic carbene (NHC) ligands for transition metal catalysis.
• Chemical Research: A valuable reagent for Sonogashira, Heck, and other palladium-catalyzed cross-coupling reactions in academic and industrial R&D settings.
• Fluorescent Probe Synthesis: Used to build conjugated π-systems for dyes, sensors, and imaging agents.

Basic Information

Product Name	1-Bromo-2-Ethynylbenzene
CAS No.	766-46-1
Molecular Formula	C8H5Br
Molecular Weight	181.03 g/mol
Synonyms	2-Bromophenylacetylene; o-Bromophenylacetylene; 2-Ethynylbromobenzene; (2-Bromophenyl)ethyne; 1-Bromo-2-ethynyl-benzene; Bromo(2-ethynylphenyl); 2-Bromoethynylbenzene
EINECS	Contact for details

Quality Control

Our 1-Bromo-2-Ethynylbenzene is manufactured under strict quality management protocols. Every batch undergoes comprehensive analytical testing, including GC, HPLC, and NMR, to ensure high purity and consistency. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment. We support cGMP compliance for advanced intermediates and can tailor specifications to meet your specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. For long-term storage, consider under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.