Description

Diethyl tert-Butylmalonate is a high-purity, versatile malonic ester derivative, serving as a critical building block in advanced organic synthesis. Its value lies in its ability to introduce the sterically hindered tert-butyl group, a key structural motif for modifying molecular properties. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries seeking to develop novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediates: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring bulky, lipophilic tert-butyl substituents to enhance metabolic stability and membrane permeability.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and plant growth regulators where the tert-butyl group can influence biological activity and environmental persistence.
• Ligand and Catalyst Development: Serves as a starting material for creating sophisticated chiral ligands and organocatalysts used in asymmetric synthesis.
• Polymer Chemistry: Employed in the synthesis of specialty monomers and polymers, where it can impart unique steric and solubility characteristics to the final material.
• Fine Chemical Manufacturing: A versatile reagent for constructing complex molecular architectures in custom synthesis and process development for various high-value chemicals.
• Research & Development: Fundamental building block in academic and industrial R&D for exploring new synthetic methodologies and creating compound libraries for screening.

Basic Information

Item	Detail
Product Name	Diethyl tert-Butylmalonate
CAS No.	759-24-0
Molecular Formula	C11H20O4
Molecular Weight	216.27 g/mol
Synonyms	Diethyl 2-(tert-Butyl)malonate; Diethyl 2-tert-Butylmalonate; 2-tert-Butylmalonic Acid Diethyl Ester; Diethyl (2-Methyl-2-propanyl)propanedioate; tert-Butylmalonic Acid Diethyl Ester; Propanedioic acid, 2-(1,1-dimethylethyl)-, diethyl ester; Diethyl 1,1-Dimethylethylmalonate
EINECS	212-067-4

Quality Control

Our Diethyl tert-Butylmalonate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including chromatography (GC/HPLC) and spectroscopic methods (NMR, IR), to verify identity and purity. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials such as strong bases and oxidizing agents. Recommended storage temperature is 2-25°C. The container should be kept tightly sealed to prevent moisture absorption.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Refractive Index (n20D)	1.425 - 1.429
Density (20°C)	0.98 - 1.02 g/mL

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.