Description

4-(Trifluoromethylthio)Acetophenone is a specialized organic building block featuring a trifluoromethylthio (-SCF₃) functional group attached to an acetophenone core. This compound matters for its unique combination of structural motifs, making it a valuable intermediate in the synthesis of advanced materials and active pharmaceutical ingredients (APIs). It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for creating novel molecules with enhanced properties.

Application

• Pharmaceutical Intermediate: A key synthon for the development of new drug candidates, particularly those requiring the metabolically stable and lipophilic trifluoromethylthio moiety.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides where the -SCF₃ group can improve biological activity and environmental stability.
• Material Science Research: Serves as a precursor for functionalized polymers, liquid crystals, or organic electronic materials due to its aromatic ketone and sulfur-containing group.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying enzyme mechanisms or protein interactions.
• Cross-Coupling Reactions: Acts as a substrate in various palladium-catalyzed cross-coupling reactions to construct complex biaryl or heteroaryl systems.
• Fluorine Chemistry Studies: A valuable compound for research into the reactivity and applications of organofluorine and organosulfur chemistry.

Basic Information

Product Name	4-(Trifluoromethylthio)Acetophenone
CAS No.	713-67-7
Molecular Formula	C₉H₇F₃OS
Molecular Weight	220.21 g/mol
Synonyms	1-[4-(Trifluoromethylthio)phenyl]ethanone; 4'-(Trifluoromethylthio)acetophenone; p-(Trifluoromethylthio)acetophenone; 4-Acetylphenyl trifluoromethyl sulfide; Ethanone, 1-[4-[(trifluoromethyl)thio]phenyl]-; 4-SCF₃-Acetophenone
EINECS	Contact for details

Quality Control

Our 4-(Trifluoromethylthio)Acetophenone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). This material is light-sensitive (store away from light) and easily oxidized (store under inert atmosphere for long-term storage). Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.