Description

4'-Methoxy-2,2,2-trifluoroacetophenone is a versatile trifluoromethylated aromatic ketone, a key building block in advanced organic synthesis. Its value lies in the unique reactivity and physicochemical properties imparted by the trifluoromethyl group, which is highly sought after in the development of modern functional materials and pharmaceuticals. This compound is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries, particularly for creating novel active ingredients and complex intermediates.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of active pharmaceutical ingredients (APIs), especially those containing trifluoromethyl motifs for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides where the trifluoromethyl group improves efficacy and environmental profile.
• Liquid Crystal & OLED Material Precursor: Serves as a key starting material for synthesizing fluorinated compounds used in electronic displays and optoelectronic devices.
• Cross-Coupling Reactions: Acts as an electrophilic coupling partner in palladium-catalyzed and other metal-mediated cross-coupling reactions to construct complex molecular architectures.
• Fluorine Chemistry Research: A valuable reagent for studying the introduction and behavior of the CF3 group in various chemical transformations.
• Fine Chemical Production: Employed in the custom synthesis of specialty chemicals, flavors, and fragrances requiring specific fluorinated structures.

Basic Information

Item	Detail
Product Name	4'-Methoxy-2,2,2-Trifluoroacetophenone
CAS No.	711-38-6
Molecular Formula	C9H7F3O2
Molecular Weight	204.15 g/mol
Synonyms	2,2,2-Trifluoro-1-(4-methoxyphenyl)ethanone; 1-(4-Methoxyphenyl)-2,2,2-trifluoroethanone; 4-Methoxy-α,α,α-trifluoroacetophenone; p-Methoxy-α,α,α-trifluoroacetophenone; 4-Methoxybenzoyltrifluoromethane; 4'-Methoxy-α,α,α-trifluoroacetophenone; Trifluoro-4'-methoxyacetophenone; 4-Methoxyphenyl trifluoromethyl ketone
EINECS	Contact for details

Quality Control

Our 4'-Methoxy-2,2,2-trifluoroacetophenone is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and IR spectroscopy, to ensure high purity and consistent performance. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment supports compliance with cGMP and ISO standards for reliable integration into regulated research and production workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed when not in use to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or crystalline solid
Identification (IR)	Conforms to structure
Purity (HPLC/GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.