Description

4'-(Trifluoromethyl)Propiophenone is a versatile fluorinated aromatic ketone building block, recognized for its unique trifluoromethyl group which imparts enhanced lipophilicity and metabolic stability to target molecules. This compound is a critical intermediate in the synthesis of advanced pharmaceutical agents and agrochemicals, where the CF3 moiety is a key pharmacophore. It is primarily sought by R&D chemists and process development teams in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecules.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in CNS drugs, anti-inflammatory agents, and kinase inhibitors.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and pesticides, leveraging the bioactivity of the trifluoromethyl group.
• Liquid Crystal & OLED Materials: Serves as a precursor in the synthesis of fluorinated organic electronic materials for displays and lighting.
• Advanced Material Science: Employed in creating specialty polymers and coatings with specific chemical resistance and surface properties.
• Organic Synthesis Building Block: Utilized in cross-coupling reactions, reductions, and Grignard reactions to introduce the propiophenone moiety with a CF3 substituent.
• Research & Development: Essential for medicinal chemistry programs and discovery research in academic and industrial laboratories.

Basic Information

Product Name	4'-(Trifluoromethyl)Propiophenone
CAS No.	711-33-1
Molecular Formula	C10H9F3O
Molecular Weight	202.17 g/mol
Synonyms	1-[4-(Trifluoromethyl)phenyl]propan-1-one; 4'-Trifluoromethylpropiophenone; p-Trifluoromethylpropiophenone; 4-(Trifluoromethyl)propiophenone; 4-Trifluoromethylpropiophenone; Propiophenone, 4'-(trifluoromethyl)-; 1-Propanone, 1-[4-(trifluoromethyl)phenyl]-
EINECS	211-921-3

Quality Control

Our 4'-(Trifluoromethyl)Propiophenone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and FTIR, to ensure high purity and consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	34 - 38 °C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.