Description

4'-(Trifluoromethyl)Acetophenone is a versatile aromatic ketone building block characterized by its trifluoromethyl substituent, which imparts unique electronic and lipophilic properties. This compound is essential for the synthesis of advanced pharmaceutical intermediates and agrochemicals, where the CF₃ group is a key pharmacophore for enhancing metabolic stability and bioavailability. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders, inflammation, and metabolic diseases.
• Agrochemical Synthesis: Used in the manufacture of herbicides, fungicides, and insecticides, where the trifluoromethyl group improves compound efficacy and environmental persistence.
• Liquid Crystal & OLED Materials: Serves as a building block for fluorine-containing liquid crystals and organic light-emitting diode (OLED) materials, enhancing their electronic properties and stability.
• Advanced Polymer Chemistry: Employed as a monomer or modifier in the production of high-performance polymers with specific optical, thermal, or surface characteristics.
• Organic Synthesis & Catalysis: A valuable substrate in cross-coupling reactions, Friedel-Crafts acylations, and as a ligand precursor in organometallic catalysis.
• Fluorine Chemistry Research: A standard reagent in academic and industrial R&D for studying the effects of fluorine substitution on molecular properties and reactivity.

Basic Information

Product Name	4'-(Trifluoromethyl)Acetophenone
CAS No.	709-63-7
Molecular Formula	C₉H₇F₃O
Molecular Weight	188.15 g/mol
Synonyms	1-[4-(Trifluoromethyl)phenyl]ethanone; 4-Acetylbenzotrifluoride; p-(Trifluoromethyl)acetophenone; 4-Trifluoromethylacetophenone; 4'-Trifluoromethylacetophenone; α,α,α-Trifluoro-4-acetyltoluene; 4-(Trifluoromethyl)phenyl methyl ketone; 709-63-7
EINECS	211-921-8

Quality Control

Our 4'-(Trifluoromethyl)Acetophenone is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing, including GC/HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and moisture. A detailed Certificate of Analysis (COA) is provided with each shipment, ensuring traceability and compliance with your specifications. We support cGMP and ISO 9001 standards for pharmaceutical and industrial applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C/59-77°F). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 98.0%
Melting Point	36 - 40 °C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.