Description

Phenyl-2,2,2-Trifluoroethyl-Ketone is a high-purity fluorinated aromatic ketone, a versatile and valuable building block in advanced organic synthesis. Its unique structure, featuring both a phenyl ring and a trifluoroethyl ketone moiety, makes it a critical intermediate for introducing fluorinated motifs into target molecules, which can dramatically alter their physical, chemical, and biological properties. This compound is essential for R&D and production chemists in the pharmaceutical, agrochemical, and specialty materials sectors seeking to develop novel compounds with enhanced metabolic stability, lipophilicity, or specific electronic characteristics.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly those requiring fluorinated aromatic systems to improve bioavailability and metabolic resistance.
• Agrochemical Synthesis: Used in creating advanced herbicides, fungicides, and insecticides where the trifluoromethyl group enhances biological activity and environmental persistence.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated components in electronic display materials, contributing to improved dielectric anisotropy and stability.
• Polymer & Resin Modifiers: Incorporated into specialty polymers to impart specific properties like chemical resistance, lower surface energy, or altered refractive index.
• Organic Synthesis Building Block: Employed in various name reactions (e.g., Friedel-Crafts acylation, Grignard reactions) to construct complex fluorinated molecular architectures.
• Research & Development: Utilized in academic and industrial labs for exploring new synthetic methodologies and the structure-activity relationships of fluorinated compounds.

Basic Information

Product Name	Phenyl-2,2,2-Trifluoroethyl-Ketone
CAS No.	709-21-7
Molecular Formula	C9H7F3O
Molecular Weight	188.15 g/mol
Synonyms	2,2,2-Trifluoro-1-phenylethanone; α,α,α-Trifluoroacetophenone; Trifluoroacetophenone; Phenyl Trifluoromethyl Ketone; 1-Phenyl-2,2,2-trifluoroethanone; Benzoyltri-fluoromethane; TFA; ω,ω,ω-Trifluoroacetophenone; NSC 404058
EINECS	211-915-7

Quality Control

Our Phenyl-2,2,2-Trifluoroethyl-Ketone is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including GC/HPLC for purity, identity confirmation by IR and NMR spectroscopy, and determination of key physical parameters. We provide full traceability and Certificates of Analysis (COA) are available for every shipment, ensuring compliance with your specific research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong bases, reducing agents, and sources of ignition. For long-term storage under an inert atmosphere, please contact us for specific recommendations.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Refractive Index (n20D)	1.456 - 1.460
Density (20°C)	1.28 - 1.32 g/mL

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.