Description

2,2,2,3'-Tetrafluoroacetophenone is a specialized fluorinated aromatic ketone of significant interest in advanced chemical synthesis. This compound matters as a versatile and high-value building block for introducing the trifluoromethyl and fluorophenyl motifs, which are critical for modulating the physicochemical properties of target molecules. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly those requiring trifluoromethylated or fluorinated aromatic systems to enhance metabolic stability, bioavailability, and binding affinity.
• Agrochemical Synthesis: Used in the research and production of modern pesticides and herbicides, where the fluorine atoms contribute to improved lipophilicity, membrane penetration, and environmental persistence.
• Liquid Crystal & OLED Materials: Serves as a precursor in the synthesis of fluorinated organic semiconductors, liquid crystal compounds, and electron-transport materials for display and lighting technologies.
• Polymer & Resin Modifier: Incorporated into specialty polymers to impart unique properties such as enhanced chemical resistance, thermal stability, and altered refractive indices.
• Organic Synthesis Building Block: Employed in various name reactions (e.g., Friedel-Crafts acylation, Grignard reactions) to construct complex, fluorinated molecular architectures in academic and industrial research.
• Dye & Pigment Intermediate: Utilized in the synthesis of specialized fluorinated dyes and pigments that offer superior lightfastness and color properties.

Basic Information

Product Name	2,2,2,3'-Tetrafluoroacetophenone
CAS No.	708-64-5
Molecular Formula	C8H4F4O
Molecular Weight	192.11 g/mol
Synonyms	2,2,2-Trifluoro-1-(3-fluorophenyl)ethanone; 1-(3-Fluorophenyl)-2,2,2-trifluoroethanone; 3-Fluoro-α,α,α-trifluoroacetophenone; α,α,α-Trifluoro-3-fluoroacetophenone; 3-Fluorophenyl trifluoromethyl ketone; 3'-Fluoro-2,2,2-trifluoroacetophenone; m-Fluoro-α,α,α-trifluoroacetophenone; 708-64-5
EINECS	211-915-1

Quality Control

Our 2,2,2,3'-Tetrafluoroacetophenone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including GC/HPLC for purity and identity confirmation via NMR and IR spectroscopy, to ensure compliance with stringent specifications. Certificates of Analysis (COA) detailing all test results are provided with every shipment to guarantee traceability and batch-to-batch consistency for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong bases, reducing agents, and sources of ignition. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Refractive Index (n20D)	1.430 - 1.440
Density (20°C)	1.35 - 1.45 g/cm³

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.