Description

(4-Fluorophenyl)Methyl-Trimethylsilane is a versatile organosilicon compound featuring a fluorinated aromatic ring, making it a valuable synthon in advanced organic synthesis. Its primary value lies in its dual functionality, serving as both a protected benzyl alcohol equivalent and a source of a fluorophenyl moiety for introducing fluorine into target molecules. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and materials science industries who require high-purity intermediates for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs) containing fluorophenyl groups, leveraging fluorine's ability to modulate bioavailability and metabolic stability.
• Agrochemical Synthesis: Used in creating advanced herbicides, fungicides, and insecticides where the fluorophenyl group enhances biological activity and environmental persistence.
• Liquid Crystal & OLED Materials: Serves as a precursor in the production of fluorinated aromatic components for electronic display materials and organic light-emitting diodes (OLEDs).
• Cross-Coupling Reactions: Acts as a reagent in palladium-catalyzed cross-coupling reactions, such as Suzuki-Miyaura or Kumada couplings, for biaryl bond formation.
• Protecting Group Chemistry: The trimethylsilyl group can act as a protecting group for alcohols or be selectively removed or transformed under mild conditions.
• Advanced Polymer Monomers: Employed in the synthesis of specialty polymers and resins with tailored thermal and chemical resistance properties.

Basic Information

Product Name	(4-Fluorophenyl)Methyl-Trimethylsilane
CAS No.	706-25-2
Molecular Formula	C10H15FSi
Molecular Weight	182.31 g/mol
Synonyms	1-[(Trimethylsilyl)methyl]-4-fluorobenzene; (4-Fluorobenzyl)trimethylsilane; 4-Fluorobenzyltrimethylsilane; Trimethyl(4-fluorobenzyl)silane; p-Fluorobenzyltrimethylsilane; 4-Fluoro-α-(trimethylsilyl)toluene; (p-Fluorophenyl)methyltrimethylsilane; α-Trimethylsilyl-4-fluorotoluene
EINECS	Contact for details

Quality Control

Our (4-Fluorophenyl)Methyl-Trimethylsilane is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for sensitive synthetic applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing purity, identity, and impurity profiles. While produced to meet the stringent requirements of research and development, specifications can be aligned with current Good Manufacturing Practice (cGMP) principles for advanced pharmaceutical applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, containers should be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.