Description

(4-Fluorophenyl)Propiolic Acid CAS NO 706-06-9 is a versatile fluorinated aromatic alkyne derivative, serving as a critical building block in advanced organic synthesis. Its unique structure, featuring both a terminal alkyne and a carboxylic acid group on a fluorinated benzene ring, makes it an invaluable precursor for constructing complex molecular architectures. This high-purity intermediate is essential for research and production in pharmaceutical development, agrochemical synthesis, and materials science.

Application

• Pharmaceutical Intermediate: Key synthon for the development of active pharmaceutical ingredients (APIs), particularly in kinase inhibitors and other targeted therapies.
• Agrochemical Synthesis: Used in the production of novel herbicides and fungicides, leveraging the fluorine atom for enhanced biological activity and metabolic stability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands in transition metal catalysis and organometallic chemistry.
• Polymer and Material Science: Building block for synthesizing fluorinated polymers, liquid crystals, and advanced organic electronic materials.
• Click Chemistry: The terminal alkyne group enables efficient Huisgen cycloaddition reactions for bioconjugation and polymer functionalization.
• Chemical Research: A valuable reagent for academic and industrial R&D in medicinal chemistry and synthetic methodology development.

Basic Information

Product Name	(4-Fluorophenyl)Propiolic Acid
CAS No.	706-06-9
Molecular Formula	C9H5FO2
Molecular Weight	164.13 g/mol
Synonyms	4-Fluorophenylpropiolic Acid; 4-Fluorobenzene-propiolic Acid; 3-(4-Fluorophenyl)prop-2-ynoic Acid; p-Fluorophenylpropiolic Acid; 706-06-9; 4-Fluorophenylacetylene carboxylic acid; 2-Propynoic acid, 3-(4-fluorophenyl)-
EINECS	Contact for details

Quality Control

Our (4-Fluorophenyl)Propiolic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and FTIR, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our commitment to quality ensures material consistency for your critical research and production needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Due to its nature as a strong acid/organic solvent and its sensitivity to oxidation, it is recommended to store the material under an inert atmosphere for long-term preservation. Keep away from heat, sparks, open flames, and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	140 - 145 °C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.