Description

Ethanone, 2,2-Difluoro-1-(4-Methylphenyl)- (9Ci) is a high-purity fluorinated aromatic ketone building block, essential for advanced organic synthesis. Its unique difluoroacetyl moiety adjacent to a methylphenyl ring makes it a valuable intermediate for creating complex molecules with tailored properties. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries seeking to incorporate fluorine for enhanced bioactivity, metabolic stability, or material characteristics.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in the development of fluorinated drug candidates for oncology, CNS, and anti-infective therapies.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the fluorine atoms can improve lipophilicity, membrane permeability, and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated components in electronic display materials and organic light-emitting diodes (OLEDs), contributing to improved charge transport and device efficiency.
• Polymer & Resin Modifier: Incorporated into specialty polymers to enhance thermal stability, chemical resistance, and surface properties for high-performance coatings and engineering plastics.
• Chemical Research & Development: A versatile reagent for exploring new fluorination methodologies and constructing complex molecular architectures in academic and industrial R&D settings.

Basic Information

Product Name	Ethanone, 2,2-Difluoro-1-(4-Methylphenyl)- (9Ci)
CAS No.	704-36-9
Molecular Formula	C9H8F2O
Molecular Weight	170.16 g/mol
Synonyms	2,2-Difluoro-1-(4-methylphenyl)ethanone; 4-Methyl-2',2'-difluoroacetophenone; 2,2-Difluoro-1-p-tolylethanone; p-Tolyl difluoroacetate ketone; α,α-Difluoro-4-methylacetophenone; 4-Methyl-α,α-difluoroacetophenone; Difluoro(p-tolyl)methanone; (4-Methylphenyl)difluoroacetyl ketone
EINECS	Contact for details

Quality Control

Our Ethanone, 2,2-Difluoro-1-(4-Methylphenyl)- (9Ci) is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment supports applications requiring high-purity intermediates under cGMP and ISO 9001 guidelines where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.