Description

Ethanone, 2,2-Difluoro-1-(2-Methylphenyl)- (9Ci) CAS NO 703-42-4 is a specialized fluorinated aromatic ketone building block, recognized for its unique difluoroacetyl moiety attached to an o-tolyl ring. This compound matters as a high-value intermediate for synthesizing complex molecules, particularly in advanced pharmaceutical and agrochemical research where the introduction of fluorine atoms is critical for modulating biological activity, metabolic stability, and lipophilicity. It is primarily needed by R&D chemists and process development scientists in the fine chemical, pharmaceutical, and crop protection industries for constructing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, especially in oncology and CNS therapeutic areas, where the difluoroacetophenone structure is leveraged.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, fungicides, and insecticides, utilizing fluorine's properties to enhance efficacy and environmental profile.
• Liquid Crystal & OLED Materials: Serves as a precursor in the development of fluorinated organic electronic materials for displays and lighting applications.
• Advanced Polymer Chemistry: Employed as a monomer or cross-linking agent in the synthesis of specialty polymers with tailored thermal and chemical resistance.
• Fluorination Reagent Research: Acts as a model substrate or a starting material in methodological studies for new fluorination reactions in academic and industrial labs.
• Complex Ligand Synthesis: Utilized for preparing fluorinated ligands used in catalysis and metal-organic frameworks (MOFs).

Basic Information

Product Name	Ethanone, 2,2-Difluoro-1-(2-Methylphenyl)- (9Ci)
CAS No.	703-42-4
Molecular Formula	C9H8F2O
Molecular Weight	170.16 g/mol
Synonyms	2',2'-Difluoro-2-methylacetophenone; 1-(2-Methylphenyl)-2,2-difluoroethanone; o-Methyl-α,α-difluoroacetophenone; 2-Methyl-α,α-difluoroacetophenone; 2,2-Difluoro-1-(o-tolyl)ethanone; Difluoro(2-methylphenyl)methanone; (2-Methylphenyl)difluoromethyl ketone; 703-42-4
EINECS	Contact for details

Quality Control

Our Ethanone, 2,2-Difluoro-1-(2-Methylphenyl)- is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure high purity and consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment. We support cGMP standards for pharmaceutical applications and can tailor specifications to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is sensitive to strong alkalis and fluorides; keep away from incompatible materials. For long-term storage under inert atmosphere, please contact our technical team for specific recommendations.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 0.5% Total impurities ≤ 2.0%
Refractive Index	Contact for details
Density	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.