Description

2-Bromo-4-(Chloromethyl)-1-Methoxybenzene is a versatile halogenated aromatic building block of significant importance in advanced organic synthesis. Its bifunctional nature, featuring both bromo and chloromethyl substituents, makes it a critical intermediate for constructing complex molecular architectures. This compound is primarily sought after by research institutions and manufacturers in the pharmaceutical and agrochemical sectors for the development of active ingredients and novel materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules requiring a substituted benzyl or phenethyl moiety.
• Agrochemical Synthesis: Used in the development of herbicides, fungicides, and insecticides, where its halogenated structure can be leveraged for bioactivity.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized phosphine or nitrogen-based ligands used in transition metal catalysis.
• Material Science Research: Employed in the synthesis of monomers for specialty polymers, liquid crystals, or organic electronic materials.
• Cross-Coupling Reactions: The bromoaryl group is amenable to Suzuki, Heck, and other palladium-catalyzed cross-coupling reactions for carbon-carbon bond formation.
• Chemical Derivatization: The reactive chloromethyl group allows for further functionalization through nucleophilic substitution, enabling the attachment of various amines, alcohols, or thiols.

Basic Information

Product Name	2-Bromo-4-(Chloromethyl)-1-Methoxybenzene
CAS No.	701-94-0
Molecular Formula	C8H8BrClO
Molecular Weight	235.51 g/mol
Synonyms	1-Bromo-2-Methoxy-5-(Chloromethyl)benzene; 4-Bromo-3-Methoxybenzyl Chloride; 2-Bromo-4-(Chloromethyl)anisole; 5-(Chloromethyl)-2-Bromoanisole; 3-Methoxy-4-Bromobenzyl Chloride; (2-Bromo-4-Methoxyphenyl)methyl Chloride; Benzene, 2-bromo-4-(chloromethyl)-1-methoxy-
EINECS	Contact for details

Quality Control

Our 2-Bromo-4-(Chloromethyl)-1-Methoxybenzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be kept in amber glass or opaque packaging.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.