Description

2'-Chloro-4'-Fluoroacetophenone is a high-purity fluorinated aromatic ketone, serving as a critical building block in advanced organic synthesis. Its value lies in providing a versatile halogenated scaffold for constructing complex molecules with tailored properties. This intermediate is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those containing fluorinated and chlorinated aromatic systems.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and pesticides, where the fluorine and chlorine substituents enhance biological activity and stability.
• Liquid Crystal & OLED Material Precursor: Serves as a starting material for synthesizing fluorinated compounds used in electronic displays and organic light-emitting diodes.
• Advanced Polymer Modification: Employed to introduce halogenated aromatic groups into polymer chains, altering thermal and chemical resistance properties.
• Organic Synthesis & Research: A versatile reagent for Friedel-Crafts acylation reactions and further functionalization in academic and industrial R&D laboratories.

Basic Information

Product Name	2'-Chloro-4'-Fluoroacetophenone
CAS No.	700-35-6
Molecular Formula	C8H6ClFO
Molecular Weight	172.58 g/mol
Synonyms	1-(2-Chloro-4-fluorophenyl)ethanone; 2-Chloro-4-fluoroacetophenone; 2-Chloro-4'-fluoroacetophenone; 2-Chloro-4-fluorophenyl methyl ketone; 2'-Chloro-4'-fluoroacetophenone; 4-Fluoro-2-chloroacetophenone; Ethanone, 1-(2-chloro-4-fluorophenyl)-; NSC 406107
EINECS	211-842-6

Quality Control

Our 2'-Chloro-4'-Fluoroacetophenone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. Certificates of Analysis (COA) with detailed specifications are provided for every shipment, supporting compliance with global regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from incompatible materials such as strong bases and fluorides. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	48 - 52 °C
Loss on Drying	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.