Description

Methyl 5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1-Benzothiophene-2-Carboxylate is a high-purity, advanced pharmaceutical intermediate featuring a benzothiophene core functionalized with both a methyl ester and a pinacol boronate ester group. This compound is a critical building block in modern synthetic chemistry, enabling efficient carbon-carbon bond formation via Suzuki-Miyaura cross-coupling reactions. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of novel active pharmaceutical ingredients (APIs), agrochemicals, and organic electronic materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of complex drug candidates, particularly those containing benzothiophene scaffolds for oncology and CNS therapies.
• Suzuki-Miyaura Cross-Coupling: Serves as a versatile boronic ester reagent for palladium-catalyzed coupling with aryl/heteroaryl halides to construct biaryl systems.
• Agrochemical Research: Building block for developing new generation herbicides, fungicides, and plant growth regulators.
• Material Science: Used in the research and development of organic semiconductors, OLEDs, and other advanced functional materials.
• Chemical Synthesis: Enables the modular construction of complex organic molecules in academic and industrial R&D laboratories.

Basic Information

Product Name	Methyl 5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1-Benzothiophene-2-Carboxylate
CAS No.	690632-26-9
Molecular Formula	C₁₆H₁₉BO₄S
Molecular Weight	318.20 g/mol
Synonyms	5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1-benzothiophene-2-carboxylic acid methyl ester; Methyl 5-(pinacolatoboryl)benzothiophene-2-carboxylate; 1-Benzothiophene-2-carboxylic acid, 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-, methyl ester; 5-(Pinacolboryl)benzothiophene-2-carboxylic acid methyl ester; CAS 690632-26-9
EINECS	Contact for details

Quality Control

Our production of Methyl 5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1-Benzothiophene-2-Carboxylate adheres to stringent quality management protocols. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, confirming compliance with customer specifications and supporting regulatory filings for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage or after opening to prevent decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.