Description

4-Methyl-2-Phenyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1,3-Thiazole is a high-value, advanced pharmaceutical intermediate and a key building block in modern organic synthesis. This compound matters because it serves as a versatile boronic ester pinacol ester, enabling critical carbon-carbon bond-forming reactions like the Suzuki-Miyaura cross-coupling, which is fundamental to drug discovery and materials science. It is primarily needed by research institutions and industrial manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors for developing novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of complex drug candidates, particularly those containing the thiazole heterocycle.
• Suzuki-Miyaura Cross-Coupling Reactions: Acts as a stable organoboron reagent for constructing biaryl and heterobiaryl structures central to many active pharmaceutical ingredients (APIs).
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides with improved efficacy.
• Material Science: Serves as a building block for creating organic electronic materials, such as those used in OLEDs and semiconductors.
• Chemical Biology & Proteomics: Employed in the synthesis of molecular probes and inhibitors for target identification and validation.
• Academic & Contract Research: A valuable reagent for methodology development and synthetic chemistry research in universities and CROs.

Basic Information

Product Name	4-Methyl-2-Phenyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1,3-Thiazole
CAS No.	690632-24-7
Molecular Formula	C16H20BNO2S
Molecular Weight	301.21 g/mol
Synonyms	2-(4-Methyl-2-phenyl-1,3-thiazol-5-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-4-methyl-2-phenylthiazole; 4-Methyl-2-phenylthiazole-5-boronic acid pinacol ester; 4-Methyl-2-phenyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)thiazole; Thiazole boronic ester pinacol ester; Pinacol 4-Methyl-2-phenyl-1,3-thiazole-5-boronate
EINECS	Contact for details

Quality Control

Our production of 4-Methyl-2-Phenyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1,3-Thiazole adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical characterization, including HPLC, NMR (1H and 13C), and mass spectrometry, to confirm identity and purity. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (argon or nitrogen) for long-term storage to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.