Description

4-Methyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-2-[4-(Trifluoromethyl)Phenyl]-1,3-Thiazole is a high-value, organoboron building block critical for modern synthetic chemistry. This compound matters as a versatile intermediate enabling the synthesis of complex molecules through efficient cross-coupling reactions, such as the Suzuki-Miyaura reaction. Pharmaceutical, agrochemical, and advanced materials research and development teams need this precise chemical to accelerate the discovery of new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly those targeting CNS disorders, inflammation, and oncology, leveraging the trifluoromethyl and thiazole pharmacophores.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, fungicides, and insecticides, where the boronic ester group facilitates the introduction of complex aromatic systems.
• Material Science Research: Serves as a building block for creating organic electronic materials, including OLED emitters and charge-transport molecules, due to its conjugated thiazole core.
• Chemical Biology Probes: Employed in the development of molecular probes and tags for studying biological processes, where its boron moiety allows for further functionalization via click chemistry.
• Cross-Coupling Reactions: Primarily utilized in palladium-catalyzed Suzuki-Miyaura couplings to form biaryl and heterobiaryl structures, which are ubiquitous scaffolds in medicinal and materials chemistry.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs and research institutions for bespoke synthesis projects requiring specific, high-purity boronic ester derivatives.

Basic Information

Product Name	4-Methyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-2-[4-(Trifluoromethyl)Phenyl]-1,3-Thiazole
CAS No.	690631-96-0
Molecular Formula	C₁₇H₁₉BF₃NO₂S
Molecular Weight	369.21 g/mol
Synonyms	2-[4-(Trifluoromethyl)phenyl]-4-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,3-thiazole; 4-Methyl-2-[4-(trifluoromethyl)phenyl]-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)thiazole; 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-[4-(trifluoromethyl)phenyl]-4-methylthiazole; [2-[4-(Trifluoromethyl)phenyl]-4-methyl-1,3-thiazol-5-yl]boronic acid pinacol ester; Thiazole Boronic Ester PIN; CAS 690631-96-0; 690631-96-0
EINECS	Contact for details

Quality Control

Our 4-Methyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-2-[4-(Trifluoromethyl)Phenyl]-1,3-Thiazole is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, essential for sensitive cross-coupling reactions. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing purity, identity, and impurity profiles. Our quality system is designed to meet the stringent requirements of pharmaceutical and advanced R&D applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic nature, the container should be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and decomposition. Recommended long-term storage temperature is 2-8°C (refrigerated) for optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.