Description

4,4-Difluoro-1,4'-Bipiperidine is a high-value, fluorinated bipiperidine derivative serving as a critical building block in advanced organic synthesis. Its core value lies in the strategic incorporation of fluorine atoms and a rigid, nitrogen-containing bicyclic structure, which are essential for modulating the physicochemical and biological properties of target molecules. This compound is primarily needed by research and development teams in the pharmaceutical and agrochemical industries for the discovery and development of new active ingredients.

Application

4,4-Difluoro-1,4'-Bipiperidine (CAS 686298-08-8) is a versatile intermediate with significant applications in research-driven industries.

• Pharmaceutical Intermediate: Serves as a key scaffold or precursor in the synthesis of novel drug candidates, particularly in central nervous system (CNS) and oncology research, where the fluorinated bipiperidine moiety can enhance metabolic stability and binding affinity.
• Agrochemical Synthesis: Used in the development of new generation pesticides and herbicides, where its structural features can contribute to improved efficacy and environmental profile.
• Chemical Biology & Proteomics: Employed as a building block for designing molecular probes, enzyme inhibitors, and tool compounds to study biological pathways.
• Ligand Development for Catalysis: Acts as a precursor for creating sophisticated nitrogen-containing ligands used in asymmetric catalysis and transition metal complexes.
• Material Science Research: Investigated as a monomer or additive for creating specialty polymers with unique properties, such as modified solubility or thermal stability.

Basic Information

Product Name	4,4-Difluoro-1,4'-Bipiperidine
CAS No.	686298-08-8
Molecular Formula	C10H18F2N2
Molecular Weight	204.26 g/mol
Synonyms	1,1'-(1,4-Piperazinediyl)bis-4-fluoropiperidine; 4,4'-Difluoro-1,4'-bipiperidine; 4-Fluoro-1-(4-fluoropiperidino)piperidine; 1,4'-Bipiperidine, 4,4'-difluoro-; 4,4'-Difluoro-[1,4']bipiperidinyl
EINECS	Contact for details

Quality Control

Our 4,4-Difluoro-1,4'-Bipiperidine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment. We support cGMP compliance for advanced applications and can tailor purity grades to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (typically 15-25°C). This compound may be hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere if specified. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Standard Grade)
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.